Tag

Exercise Pill

All articles tagged with #exercise pill

health8 days ago•6 min saved

Experimental Pill Tries to Turn Exercise Into a Daily Tablet

Enveda’s ENV-308 is an experimental daily pill designed to mimic some effects of exercise by delivering Lac-Phe to suppress appetite. In a Phase 1 trial with 88 healthy adults, the drug was safe and well tolerated across dose levels, with an “exceptional” gastrointestinal safety profile. Lac-Phe is a natural compound formed when lactate and phenylalanine combine during exercise and can reduce hunger, but it degrades quickly; ENV-308 aims to prolong these effects and potentially complement GLP-1 weight-loss drugs. Animal studies suggest it may preserve lean muscle during weight loss. Next steps include trials to test actual weight and metabolic outcomes and interactions with other therapies. Even if successful, it will take years and FDA approval before it could reach patients, and it won’t replace the benefits of physical activity.

via New York Post|

#env-308 #exercise-pill #glp-1

science9 days ago•3 min saved

Could an Exercise Pill Pass Its First Human Safety Check? ENV-308

Enveda’s ENV-308, a pill designed to mimic the exercise-linked molecule Lac-Phe, successfully completed a Phase I trial in 88 healthy volunteers, showing safety, tolerability, and an exceptional GI safety profile. Early signs suggest it may influence leptin levels and aid weight maintenance and muscle preservation, with Phase II planned for weight-loss maintenance and exploration in migraines and inflammatory bowel disease. It’s not a substitute for real exercise, but could offer a convenient metabolic aid as development continues.

via Gizmodo|

#env-308 #exercise-pill #lac-phe

health-and-medicine2 years ago•3 min saved

"Exercise Mimetics: The Promise of Fitness Benefits in a Pill"

Scientists in the US have developed a potential "exercise pill," called SLU-PP-332, that mimics some of the benefits of exercise by targeting a natural metabolic pathway usually triggered by physical activity. In experiments on mice, the drug improved muscle function, fitness, and endurance without requiring increased physical activity. The drug's development represents a breakthrough in targeting a previously thought "undruggable" metabolic pathway, with potential applications for treating diseases like neurodegenerative conditions and heart failure. While not a perfect substitute for exercise, the pill shows promise in conveying exercise benefits to various organs and tissues, and may be particularly beneficial for individuals unable to exercise due to aging, certain diseases, or muscle loss.

via ScienceAlert|

#drug-development #exercise-pill #fitness

health-and-science2 years ago•2 min saved

"Pill Mimics Exercise Benefits: A Lazy Person's Dream Come True"

Scientists have developed compounds that mimic the physical benefits of exercise, potentially leading to the creation of an 'exercise pill' in the future. The pill aims to enhance metabolism, muscle growth, and performance, and could be beneficial for individuals unable to exercise due to medical conditions. While successful in rodent cells, further testing is needed before it can be considered for human use.

via BBC Science Focus|

#exercise-pill #health-and-science #medical-conditions

health-and-science2 years ago•3 min saved

"Pill Mimicking Exercise: The Lazy Person's Solution to Fitness"

Researchers have discovered new chemical compounds that mimic the health benefits of exercise, potentially leading to a pill that could offset muscle atrophy and weakness in individuals who cannot exercise for medical reasons or have conditions causing muscle wasting. The compound, SLU-PP-332, activates estrogen-related receptors in muscles, leading to increased fatigue-resistant muscle fibers and improved endurance in mice. The researchers believe these compounds could have therapeutic potential for conditions like declining kidney function, heart failure, obesity, and neurodegenerative diseases, offering hope for improving the quality of life for individuals facing muscle-related challenges.

via Newsweek|

#american-chemical-society #exercise-pill #health-and-science