Aging-protein blocker regenerates knee cartilage, signaling arthritis reversal
Blocking the aging-related enzyme 15-PGDH reprograms existing cartilage cells to regrow hyaline cartilage in aged mice and human knee tissue, prevents osteoarthritis after ACL-type injuries, and could be delivered by injection or an oral drug; the approach might reduce the need for joint replacements if proven in people, and related clinical trials for the inhibitor are already underway for other aging-related conditions; researchers note the regeneration comes from changing existing chondrocytes rather than stem cells, and there are patent/licensing ties involved.
