Naked Mole Rat Longevity Gene Extends Mice Lifespan and Health
Researchers inserted the naked mole rat version of the HAS2 gene into mice, boosting production of high-molecular-weight hyaluronan, modestly extending median lifespan and improving health by reducing chronic inflammation, cancer risk, and age-related gut barrier decline. The work suggests longevity traits can be portable across mammals and points to human therapies that boost high-molecular-weight hyaluronan or slow its breakdown, though careful balance and tissue-specific effects will be crucial.