All articles tagged with #il 10
A UK-Denmark study links the IBD-associated HLA-DRB1*01:03 variant to antibodies that neutralize interleukin-10, removing its anti-inflammatory brake and driving disease in about 3.5% of patients (2.5% Crohn’s, 4.4% ulcerative colitis); the finding, published in The New England Journal of Medicine, points to targeted therapies for this subgroup.
A new Science Immunology study links IL-10–producing monocytes to an immune brake that dampens pain after injury. In mice, males had more IL-10–producing cells and recovered faster, with pain lasting longer when IL-10 or its receptor was blocked. Human data from the AURORA trauma study showed higher IL-10 levels at injury in men and lower subsequent pain, suggesting a biological basis for women’s longer-lasting pain. While not the sole pathway for all chronic pain, the findings point to immune signaling as a potential target, with ideas like skin-applied testosterone to modulate IL-10–positive monocytes under exploration (noting more research is needed).
New research in mice and humans suggests that immune cells produce IL-10 to help resolve pain, and sex differences in this response—shaped by testosterone—may explain why women often recover more slowly from injury and have a higher risk of chronic pain. These findings point to therapies that boost the body's natural pain-resolution system rather than only blocking pain signals.
A Michigan State University study shows IL-10–producing monocytes actively resolve inflammatory pain; higher testosterone in males boosts these cells, leading to faster pain relief, while females’ monocytes are less active and pain persists longer. This immune-driven mechanism suggests non-opioid treatments that enhance IL-10 signaling could prevent chronic pain.
The study reveals that TCF1 and LEF1 transcription factors are crucial for the maintenance, development, and regulatory function of B-1a cells in mice and humans, promoting IL-10 production and limiting inflammation, with implications for immune regulation and autoimmune diseases.