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Immunology

All articles tagged with #immunology

Blocking blood-borne T cells reverses age-related memory decline in mice
science11 days ago

Blocking blood-borne T cells reverses age-related memory decline in mice

A mouse study finds aging CD8+ T cells circulating in the blood promote cognitive ageing by secreting an enzyme that inflames the brain and impairs regeneration; blocking their blood-borne effects improved memory and learning in old mice, suggesting a practical blood-targeted approach to mitigate age-related cognitive decline. Parabiosis and cell-transfer experiments indicate these non-infiltrating T cells drive ageing, and aged cells can dampen memory-related gene expression in young brains.

via Nature|
#aging#blood-brain-axis#cd8-t-cells
3D Imaging Reveals How Killer T Cells Attack Cancer Inside Tumors
science18 days ago

3D Imaging Reveals How Killer T Cells Attack Cancer Inside Tumors

Researchers used cryo-expansion microscopy to preserve near-native cell structure and visualize cytotoxic T lymphocytes at the immune synapse in 3D, revealing a dome-shaped contact interface and variations in cytotoxic granules. Extending the technique to human tumor tissues, the team could observe T cells infiltrating tumors and deploying their killing machinery at nanometer-scale resolution, offering insights that could guide improvements in immuno-oncology therapies.

via SciTechDaily|
#cancer-immunotherapy#cryo-expansion-microscopy#cytotoxic-t-lymphocytes
Odyssey Therapeutics floats a $304M IPO to become a 'little large pharma'
business18 days ago

Odyssey Therapeutics floats a $304M IPO to become a 'little large pharma'

Odyssey Therapeutics priced a 15.5 million-share IPO at $18 to raise about $304 million (including a 1.4 million-share private placement with a TPG Life Sciences affiliate; the deal could grow by roughly $41.8 million if underwriters exercise the greenshoe). The proceeds will fund OD-001, a RIPK2 inhibitor for ulcerative colitis in phase 2, and move the preclinical SLC15A4 program into phase 1/2a, among other assets, as CEO Gary Glick pursues a 'little large pharma' model. Odyssey has raised about $726.5 million to date and will list on Nasdaq as ODTX.

via Fierce Biotech|
#biotech#business#drug-development
Trial Suggests Liver Transplants Could Free Recipients From Lifelong Immunosuppressants
health1 month ago

Trial Suggests Liver Transplants Could Free Recipients From Lifelong Immunosuppressants

A small University of Pittsburgh study tested donor-derived regulatory dendritic cell therapy to train recipients’ immune systems to accept a transplanted liver. Among 13 living-donor liver recipients, cells were given before transplant and patients remained on standard immunosuppressants for a year; eight were weaned off, with four stopping entirely and three staying drug-free for about three years on average. The trial raised the drug-free success rate to 37.5% from the typical 13–16%, but researchers caution that results are early and require larger, comparative studies to confirm effectiveness and optimize treatment.

via Gizmodo|
#clinical-trial#health#immunology
Tattoo Ink May Trigger Rare Eye Inflammation with Vision Loss
health2 months ago

Tattoo Ink May Trigger Rare Eye Inflammation with Vision Loss

Tattoo-associated uveitis is a rare immune-driven eye inflammation that can occur after getting a tattoo, potentially allowing ink-related immune responses to breach the eye’s blood-ocular barrier. While most people don’t react to tattoo inks, some develop inflammation in the uvea that can lead to glaucoma, cataracts, or permanent vision loss if untreated. Larger tattoos and black ink may pose higher risk, and individuals with autoimmune or inflammatory conditions might be more susceptible. Treatments include steroid eye drops or injections and, in some cases, long-term immunosuppressants, but about 75% experience temporary vision loss and 17% permanent loss. If you notice swelling, pain, or redness around the eye, seek prompt evaluation from an optometrist or ophthalmologist; the number of cases may rise as tattoos remain popular.

via ScienceAlert|
#eye-inflammation#health#immunology
Two genetic twists behind rare vaccine-induced clots, study finds
health2 months ago

Two genetic twists behind rare vaccine-induced clots, study finds

A global study of 100 VITT patients shows that the rare clotting after adenovirus-based vaccines arises when antibodies that initially target an adenoviral protein mutate once on a common immune gene background, enabling strong binding to platelet factor 4 and clot formation. This two-event trigger—inheritance of a specific immune gene variant and a rare mutation in antibody-producing cells after exposure—helps explain VITT’s rarity and could guide safer vaccine designs while preserving the value of adenovirus-based vaccines.

via The Conversation|
#adenovirus#blood-clots#health
TRMs empower non-invasive immune monitoring with skin-ready microneedles
immunology2 months ago

TRMs empower non-invasive immune monitoring with skin-ready microneedles

The study combines skin-resident memory T cell (TRM) recall with hydrogel-coated microneedle patches to non-invasively sample antigen-specific T cells from skin and blood. In mice, TRM priming and recall at the skin enabled sampling of thousands of live antigen-specific lymphocytes, surpassing conventional peripheral blood assessments. In a human case of allergic contact dermatitis, TRM reactivation followed by microneedle application captured diverse immune cells and cytokines from the interstitial fluid, with sampling efficiency comparable to or better than suction blisters and better suitability for longitudinal monitoring. The approach is antigen-agnostic and could enable broad, repeated immune monitoring across vaccination, infection, and autoimmune contexts, though larger cohorts and antigen-defined readouts are needed for broader clinical translation.

via Nature|
#immune-monitoring#immunology#microneedle-patches
Stanford Study Reverses Type 1 Diabetes in Mice with Dual-Transplant, No Immunosuppression
science2 months ago

Stanford Study Reverses Type 1 Diabetes in Mice with Dual-Transplant, No Immunosuppression

Stanford researchers cured type-1 diabetes in mice for six months using a dual transplant of pancreatic islet cells and donor hematopoietic stem cells to create a hybrid immune system, eliminating the need for insulin or immune-suppressing drugs. In the study, 19 of 19 treated mice remained diabetes-free and 9 of 9 long-standing diabetics were cured, though translating the approach to humans will require overcoming donor cell sourcing and scaling challenges.

via Good News Network|
#diabetes#immunology#islet-cells
Bioengineered insulin implant hints at needle-free diabetes care
science3 months ago

Bioengineered insulin implant hints at needle-free diabetes care

Scientists report a living implant that houses insulin-producing cells to regulate blood glucose, potentially replacing injections if it works in humans; animal tests show year-long sugar control but immune barriers, safety concerns, and donor cell supply still pose challenges, with next steps including human trials and adaptive uses for other diseases.

via Earth.com|
#artificial-pancreas#diabetes#immunology
Brain T Cells Sacrifice Themselves to Halt Parasite Spread, Study Finds
science3 months ago

Brain T Cells Sacrifice Themselves to Halt Parasite Spread, Study Finds

Researchers in mice found that CD8+ T cells infected by the brain parasite Toxoplasma gondii can trigger caspase-8–mediated self-destruction, killing the parasite-containing cells and preventing spread in the brain; absence of caspase-8 in these T cells leads to more brain infection, revealing a surprising protective role for T cell death and suggesting new avenues for toxoplasmosis treatment.

via ScienceAlert|
#casapase-8#cd8-tcells#immunology
Tumors hijack brain signals through nerves to dampen immune defense
science3 months ago

Tumors hijack brain signals through nerves to dampen immune defense

A Nature study in mice shows that lung cancer cells connect with nearby sensory neurons to send a signal to the brain that suppresses tumor-killing immune cells at the tumor site, allowing cancer to grow. Disabling these neurons reduced tumor growth by more than 50%, revealing a tumor-to-brain–immune axis that could be targeted to boost anticancer defenses.

via Nature|
#brain-tumor-signaling#immunology#lung-cancer