Blocking ZMYND8 Reverses T Cell Exhaustion by Restoring IL-2 Signaling
Researchers identified ZMYND8 as a key epigenetic factor that drives CD8+ T cell exhaustion by suppressing IL-2 receptor signaling. Blocking ZMYND8 restores T cell function and enhances anti-tumor and anti-viral responses, particularly when combined with IL-2 therapy or checkpoint inhibitors.