Tag

Incretin

All articles tagged with #incretin

science3 hours ago•8 min saved

Trojan-Horse Weight-Loss Molecule Delivers Potent Results in Mice

Scientists at Helmholtz Munich created a hybrid 'Trojan horse' drug that uses GLP-1R/GIPR signaling as an entry door and carries lanifibranor to activate PPARα/γ/δ inside cells, hitting five targets. In diet-induced obese mice, it reduced appetite, produced greater weight loss, and improved blood glucose versus reference therapies, with GI side effects similar to current incretin medicines. The approach is preclinical; whether results translate to humans remains to be seen and will require clinical development.

via SciTechDaily|

#diabetes #gip #glp-1

science26 days ago•65 min saved

Unimolecular quintuple agonist improves obesity and diabetes in mice

Researchers designed a unimolecular quintuple agonist (GLP-1R–GIPR–PPARα/γ/δ) that couples incretin signaling with PPAR activity to target GLP-1R/GIPR-expressing cells. In obese and insulin-resistant mice, the GLP-1–GIP–Lani compound produced greater weight loss, reduced food intake, and improved glucose tolerance and insulin sensitivity versus GLP-1R–GIPR co-agonism and semaglutide, with effects requiring GLP-1R, GIPR and PPARδ. Transcriptomic and proteomic data show anti-inflammatory hepatic and muscular programs and increased tissue glucose uptake, while safety signals remained favorable and efficacy extended to db/db mice, highlighting strong therapeutic potential for obesity and type 2 diabetes.

via Nature|

#diabetes #incretin #obesity