All articles tagged with #inflammasome
Researchers have identified functional chimeric mRNAs in mammalian cells that form through trans-splicing during inflammation. These hybrid transcripts, specifically a fusion of gasdermin D and Tmem106a, produce proteins that enhance pore formation and cytokine release in macrophages, balancing antibacterial defense against sepsis risks.
Researchers have discovered that the rare autoimmune disorder CAPS is caused by the overactivation of the NLRP3 inflammasome, which can be influenced by mechanical signaling. This condition, characterized by lifelong symptoms including rashes, joint pain, and hearing loss, has been linked to a protein complex that triggers extreme inflammatory activity. The study suggests that targeting the PIEZO/KCNN4 pathway may offer new therapeutic strategies for treating CAPS and other NLRP3-related inflammatory diseases.
Implanting electrodes into the brain triggers inflammation by activating a group of immune signaling proteins called the inflammasome, which detects infection and prompts a strong inflammatory response, a new study shows. These findings may open new avenues to improve deep brain stimulation, a type of therapy used in Parkinson’s disease and other neurological disorders to ease patients’ symptoms. The study also suggests that blocking inflammasome activation may help prevent the inflammatory response to implanted electrodes in the brain.