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Islet Cells

All articles tagged with #islet cells

science21 days ago•13 min saved

Autologous CiPSC Islet Transplant Brings Insulin Independence to Type 1 Diabetes Patient

A 25-year-old woman with lifelong Type 1 diabetes received an autologous transplant of chemically induced pluripotent stem cell–derived pancreatic islet cells, transplanted into the abdominal wall in 2023. Within 75 days she stopped needing insulin and achieved non-diabetic HbA1c with over 98% time in range, marking a first proof-of-concept for patient-derived islet cells. However, the result comes from a single case with prior immunosuppression from a liver transplant, and durability and broader applicability require more patients and longer follow-up.

via Space Daily|

#autologous-transplant #cipsc #insulin-independence

technology3 months ago•4 min saved

Oxygen-powered implant lets encapsulated islet cells regulate diabetes without immunosuppression

MIT researchers have developed an implantable, encapsulated islet-cell device with an onboard oxygen generator that protects the cells from immune attack and sustains insulin production. In mice and rats, the device functioned for at least 90 days, maintaining healthy blood glucose by the donor or stem-cell–derived islets, with wireless power delivery boosting oxygen supply. The team aims to extend durability to years and explore delivering other protein therapies in the body.

via MIT News|

#diabetes #immune-protection #implantable-device

science4 months ago•43 min saved

Stanford Study Reverses Type 1 Diabetes in Mice with Dual-Transplant, No Immunosuppression

Stanford researchers cured type-1 diabetes in mice for six months using a dual transplant of pancreatic islet cells and donor hematopoietic stem cells to create a hybrid immune system, eliminating the need for insulin or immune-suppressing drugs. In the study, 19 of 19 treated mice remained diabetes-free and 9 of 9 long-standing diabetics were cured, though translating the approach to humans will require overcoming donor cell sourcing and scaling challenges.

via Good News Network|

#diabetes #immunology #islet-cells

health1 year ago•2 min saved

Breakthrough Treatments Show Promise for Curing Severe Type 1 Diabetes

A new stem cell treatment developed by Vertex Pharmaceuticals shows promise in curing severe type 1 diabetes, with a clinical trial demonstrating significant improvements and reduced insulin dependence in most participants, though further studies are needed to confirm long-term benefits.

via ScienceAlert|

#clinical-trial #health #insulin-independence

health2 years ago•4 min saved

Revolutionary Under-Skin Implant Reverses Type 1 Diabetes Without Drugs

Researchers from Cornell and the University of Alberta have developed a new technique to treat Type 1 diabetes by implanting a device under the skin that can secrete insulin without the need for immunosuppression. The device, named SHEATH (Subcutaneous Host-Enabled Alginate THread), is inserted into a pocket created by nylon catheters, allowing blood vessels to form around it. The device provides a long-term and less invasive alternative to insulin injections or traditional transplants, and future versions may last for two to five years before needing replacement. Additional research is needed to support long-term functionality in large-animal models and eventually patients.

via Cornell Chronicle|

#health #immunosuppression #implant