All articles tagged with #mast cells
New mouse studies show scratching bug bites increases swelling by triggering mast cells via pain signals and histamine, creating an itch–scratch cycle. Menthol and anti-itch creams can temporarily relieve, and researchers are pursuing targeted treatments (MRGPRX2 blockers). In the meantime, avoid scratching and use hydrocortisone, calamine, or oatmeal baths to calm itch.
Researchers have discovered a significant link between the stress hormone corticotropin-releasing factor (CRF) and alcohol withdrawal headaches. CRF activates mast cells in the dura, triggering pain signals during alcohol withdrawal. This finding could lead to targeted drug therapies for alleviating pain during alcohol withdrawal and potentially breaking the cycle of addiction.
A study using mouse models of food allergy has found that allergic sensitization can lead to antigen-specific avoidance behavior. The ingestion of allergens activates brain areas associated with aversive stimuli, and this avoidance behavior is dependent on IgE antibodies and mast cells. The study also revealed that genetic background can influence the extent of avoidance behavior. These findings suggest that the immune system can modify behavior to promote the avoidance of unfavorable environments.
A new study from Stanford University has found that people who have asthma or eczema could be at a higher risk of developing osteoarthritis. The research suggests that existing allergy medications could block an allergic pathway to help slow the progression of the degenerative joint disease. Among the people who had asthma or eczema, there was a 58% greater risk of developing osteoarthritis within a decade. The risk jumped to 115% for those who had both asthma and eczema. The study's main limitation stems from the fact that it relies on self-reported claims data, which is "imperfect."