All articles tagged with #eczema
New research identifies a brain-to-skin neural circuit that, under stress, activates eosinophils and fuels inflammation in atopic dermatitis, explaining how psychological stress worsens eczema in both mice and humans (51 participants showed higher stress and more inflammation).
A Science study shows a brain-to-skin neural circuit where stress activates sympathetic nerves that drive eosinophils, worsening eczema. In mice, reducing eosinophils diminished the stress-related flare, while in humans higher stress correlated with more inflammation and eosinophils, suggesting potential therapies that target this neuroimmune pathway to alleviate eczema symptoms.
Corvus Pharmaceuticals reports encouraging early-stage results for its oral eczema treatment soquelitinib: after eight weeks, 75% of treated patients reached EASI-75 and 33% achieved clear or almost clear skin versus 20% and none on placebo, suggesting potential superiority to Dupixent, though data are preliminary and from a small trial.
Johnson & Johnson has discontinued its mid-stage trial of the experimental eczema drug JNJ-5939 after it failed to meet efficacy goals, but remains committed to developing other treatments for atopic dermatitis.
A young runner was misdiagnosed with shingles after developing a rash during marathon training, leading to an 8-hour ER visit and unnecessary treatment before being correctly diagnosed with eczema, highlighting issues in medical diagnosis and costs.
Eczema is a chronic inflammatory skin condition affecting about 10% of U.S. adults and children, characterized by red, itchy skin, with no current cure, making treatment challenging.
Maternal prenatal stress triggers early-life eczema in offspring by programming fetal mast cells through elevated corticosterone levels, leading to skin barrier alterations and heightened mechanical sensitivity, with effects reversible by corticosterone normalization.
Research shows children with higher levels of triclosan in their urine are 23% more likely to develop eczema symptoms, highlighting concerns over its presence in various personal care products despite regulatory restrictions.
Apogee Therapeutics' promising eczema drug showed strong efficacy in Phase 2 trials, outperforming rivals like Sanofi's Dupixent, but its shares fell sharply after the announcement. The drug could potentially rival Sanofi's top revenue-generating treatments if further trials succeed, with plans for Phase 3 testing in 2026.
Nektar Therapeutics' stock surged over 90% after successful midstage trial results for its eczema drug rezpegaldesleukin, which showed significant symptom improvement and demonstrated a new biological approach to treating inflammatory and autoimmune skin conditions.
Research suggests that early exposure to dogs may help protect children with certain genetic profiles from developing atopic eczema, a common chronic skin condition, by influencing immune response and skin barrier health. However, the effect varies among individuals, and more diverse studies are needed to confirm these findings across different populations.
Recent research suggests that air pollution, particularly fine particulate matter (PM2.5), may increase the risk of developing eczema, with higher rates observed in heavily polluted areas. This study, conducted by Yale University, highlights the potential health implications of air pollution, which has also been linked to autism risk in children when exposed during pregnancy. The findings underscore the need for stricter pollution control measures, as air pollution is a significant global health concern.
A study by UC San Francisco published in JAMA Dermatology found that consuming an extra gram of sodium daily can increase the risk of eczema flare-ups by 22%. Researchers analyzed medical records and urine samples from over 215,000 UK residents and 13,000 Americans, linking higher sodium intake to increased chances and severity of eczema.
A new study from the University of California, San Francisco, has found that consuming salty foods significantly increases the risk of eczema flare-ups. Each additional gram of sodium per day raises the likelihood of developing eczema by 22 percent. The research, which analyzed data from over 215,000 people, suggests that high salt intake may promote the growth of staphylococcus aureus bacteria, leading to skin irritation. With 90 percent of Americans consuming too much salt, reducing sodium intake could help manage eczema symptoms.
A UCSF study reveals that consuming just one extra gram of sodium daily can increase the risk of eczema flares by 22%, suggesting that reducing salt intake could help manage the condition. Researchers analyzed data from over 215,000 people and found a significant correlation between higher sodium levels and increased eczema severity.