Tag

Mimetics

All articles tagged with #mimetics

science1 month ago•60 min saved

Calorie restriction: a double-edged path to aging and healthspan

This Nature Aging review examines how different dietary restriction (DR) strategies—caloric, protein, fasting, and time-restricted regimens—affect aging and disease across mammals, highlighting common longevity pathways (autophagy, NAD+, AMPK, mTOR) and potential DR mimetics (FGF21, sirtuins, GLP-1). DR can improve healthspan and delay cancer, cardiovascular disease, and neurodegeneration in preclinical models, but effects vary by genotype, sex, species, and age at initiation, and DR may impair immune function and wound healing. The article discusses physiological adaptations (hunger, body temperature, fat loss) and translational challenges to humans, emphasizing the need for personalized approaches and cautious development of DR mimetics.

via Nature|

#aging #calorie-restriction #dietary-restriction

health-and-science2 years ago•8 min saved

"Revolutionary Exercise Pill Mimics Workout Benefits Without the Effort"

Researchers are making strides in the development of mimetics, experimental drugs that mimic the effects of exercise and calorie restriction in the body without the need for physical activity or dietary changes. These drugs have shown promising results in animal studies, with potential applications in preventing and treating conditions such as muscle loss, diabetes, heart failure, and neurodegenerative disorders. While not yet available for human use, several mimetics have moved into human trials, with the potential for FDA approval in the next 4-5 years. Mimetics could offer a way to extend healthspan and lifespan, preserve muscle, and provide health benefits without the need for strict dieting or exercise.

via Medscape|

#calorie-restriction #drug-development #exercise