Tag

Muscle Wasting

All articles tagged with #muscle wasting

science2 hours ago•7 min saved

LASSS Turns HGF into 'Super HGF' to Fight Aging Muscle Loss

Researchers report that lipoic acid trisulfide (LASSS) binds hepatocyte growth factor (HGF) to create a “Super HGF” with more than double the binding affinity to the c-met receptor and increased resistance to nitration. In aging/disuse mouse models, LASSS pretreatment reduced HGF nitration and preserved muscle repair signaling, suggesting a potential therapy for sarcopenia and disuse atrophy across mammals. The findings were published July 24, 2026 in Scientific Reports.

via Neuroscience News|

#aging #c-met #hgf

health-and-science2 years ago•3 min saved

"Unveiling the Genetic Influence on Muscle Mass Acquisition and Preservation"

New research from Northwestern University has revealed a previously unknown connection between the BCL6 gene, known for its role in immune cells, and the establishment and maintenance of skeletal muscle mass and strength in mice. The study found that the gene plays a crucial role in controlling muscle mass, impacting protein synthesis and degradation. This discovery opens up potential avenues for exploring treatments for conditions that cause muscle wasting, such as nerve injuries, nutrient deficiency, cancer, and immobility, which currently lack specific medical treatments for muscle loss.

via Northwestern Now|

#bcl6-gene #gene-function #health-and-science

health2 years ago•3 min saved

Reviving Aging Muscles and Nerves: The Breakthrough Discovery

Scientists at Stanford University School of Medicine and Sanford Burnham Prebys have discovered a new approach to accelerate recovery from peripheral nerve injury by targeting an enzyme associated with aging. Inhibiting this enzyme in a mouse model promoted the regeneration of motor nerves and formation of neuromuscular synapses, leading to faster recovery of strength. The enzyme, called 15-hydroxyprostaglandin dehydrogenase (15-PGDH), degrades a compound called prostaglandin E2 (PGE2) that is crucial for muscle regeneration. Inhibiting 15-PGDH could be a potential treatment for nerve damage and muscle wasting disorders.

via SciTechDaily|

#aging-enzyme #health #muscle-wasting