Japanese Study Finds Sulfur Compound Boosts Muscle Repair Signal
Kyushu University researchers discovered that lipoic acid trisulfide (LASSS) can enhance the binding of a key muscle repair protein, potentially improving age-related muscle recovery.
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LASSS Turns HGF into 'Super HGF' to Fight Aging Muscle Loss
Researchers report that lipoic acid trisulfide (LASSS) binds hepatocyte growth factor (HGF) to create a “Super HGF” with more than double the binding affinity to the c-met receptor and increased resistance to nitration. In aging/disuse mouse models, LASSS pretreatment reduced HGF nitration and preserved muscle repair signaling, suggesting a potential therapy for sarcopenia and disuse atrophy across mammals. The findings were published July 24, 2026 in Scientific Reports.
Sulfur compound unlocks stronger HGF signaling to boost aging muscle repair
Kyushu University researchers report that lipoic acid trisulfide (LASSS), a sulfur-based antioxidant, can bind to hepatocyte growth factor (HGF) and enhance its interaction with the c-Met receptor while reducing nitration. This creates a more active form of HGF—dubbed a potential “Super HGF”—that strengthens muscle repair in aging. In lab tests and a mouse model of muscle atrophy, LASSS improved HGF signaling and resisted damage much more effectively than glutathione trisulfide (GSSSG). While promising for preserving muscle health during aging or inactivity, further in vivo safety and efficacy studies are needed before considering human use.