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Hgf

All articles tagged with #hgf

science2 hours ago•7 min saved

LASSS Turns HGF into 'Super HGF' to Fight Aging Muscle Loss

Researchers report that lipoic acid trisulfide (LASSS) binds hepatocyte growth factor (HGF) to create a “Super HGF” with more than double the binding affinity to the c-met receptor and increased resistance to nitration. In aging/disuse mouse models, LASSS pretreatment reduced HGF nitration and preserved muscle repair signaling, suggesting a potential therapy for sarcopenia and disuse atrophy across mammals. The findings were published July 24, 2026 in Scientific Reports.

via Neuroscience News|

#aging #c-met #hgf

health-and-medicine9 hours ago•6 min saved

Sulfur compound unlocks stronger HGF signaling to boost aging muscle repair

Kyushu University researchers report that lipoic acid trisulfide (LASSS), a sulfur-based antioxidant, can bind to hepatocyte growth factor (HGF) and enhance its interaction with the c-Met receptor while reducing nitration. This creates a more active form of HGF—dubbed a potential “Super HGF”—that strengthens muscle repair in aging. In lab tests and a mouse model of muscle atrophy, LASSS improved HGF signaling and resisted damage much more effectively than glutathione trisulfide (GSSSG). While promising for preserving muscle health during aging or inactivity, further in vivo safety and efficacy studies are needed before considering human use.

via ScienceDaily|

#aging #antioxidants #health-and-medicine