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Myelin Regeneration

All articles tagged with #myelin regeneration

science1 month ago•92 min saved

Grey-matter microglia coordinate repair after focal white-matter demyelination

A targeted white‑matter lesion in a defined neural circuit triggers a transient grey‑matter microglial response, synapse loss, and reduced neuronal activity upstream of the lesion; these changes resolve as remyelination proceeds. Blocking microglia impairs remyelination, while aging diminishes this regenerative grey‑matter response, leading to chronic inflammation. The study reveals a circuit‑level regenerative plasticity that couples white‑matter integrity to grey‑matter function and suggests myelin‑regenerative therapies could mitigate chronic neuroinflammation in MS and related diseases.

via Nature|

#demyelination #microglia #myelin-regeneration

science-and-technology2 years ago•4 min saved

Revolutionary Discovery: Regenerating Myelin through Neurological Breakthrough

Researchers have discovered a new biological mechanism involving the Daam2 protein and CK2α kinase that regulates myelin repair and regeneration. This breakthrough has implications for treating neurological diseases such as multiple sclerosis and cerebral palsy. The study found that Daam2 phosphorylation impacts different stages of oligodendrocyte development, accelerating the conversion of precursor cells to glial cells in early stages but slowing down their maturation and ability to produce myelin in later stages. The researchers also identified CK2α as the kinase responsible for phosphorylating Daam2, and found that this phosphorylation plays a protective role in developmental and behavioral recovery after brain injury and facilitates remyelination in adult animals. This study opens up new therapeutic avenues for repairing and restoring myelin in neurological diseases.

via SciTechDaily|

#ck2a-kinase #daam2-protein #myelin-regeneration