Tag

Non Hormonal

All articles tagged with #non hormonal

Meiosis-Blocking Drug Shows Non-Hormonal Path to Male Birth Control in Mice
science2 days ago

Meiosis-Blocking Drug Shows Non-Hormonal Path to Male Birth Control in Mice

Cornell researchers showed that the non-hormonal drug JQ1 can temporarily halt sperm production by blocking meiosis in male mice, with fertility returning and offspring normal after stopping treatment. While JQ1 itself is unlikely to be developed due to side effects and short half-life, the study provides a proof of concept for non-hormonal male birth control and underscores multiple other candidates and approaches in the field seeking long-lasting, non-hormonal options.

Gene discovery brings male contraception closer to reality.
health3 years ago

Gene discovery brings male contraception closer to reality.

Researchers at Washington State University have identified a gene, Arrdc5, that is expressed only in testicular tissue and is found in multiple mammalian species, including humans. Knocking out the gene in male mice created infertility by impacting their sperm count, movement, and shape. The protein encoded by this gene is required for normal sperm production, and the team will work on designing a drug that would inhibit its production or function, making it easily reversible as a contraceptive. The discovery could pave the way for a highly effective, reversible, and non-hormonal male contraceptive for humans and animals.