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Osteocytes

All articles tagged with #osteocytes

science5 hours ago•5 min saved

Shinbone Compression Triggers Brain Repair via Blood-Borne Signals

Researchers at Southern Medical University in China found that applying rhythmic pressure to the shinbone of mice and pigs with brain injuries significantly improved survival and neurological recovery. The study, published in Nature Neuroscience, demonstrates a bidirectional 'bone-brain axis' where mechanical stimulation of bone cells releases protective chemicals into the bloodstream that reduce inflammation and promote neuron repair in the brain.

via ScienceAlert|

#bone-biology #neuroscience #osteocytes

science3 days ago•42 min saved

Tibial Compression Boosts Brain Recovery via Osteocyte Signaling

A new study in Nature Neuroscience demonstrates that mechanical compression of the tibia bone significantly improves survival and cognitive recovery in mice and pigs suffering from stroke or traumatic brain injury (TBI). The research identifies a direct 'bone-brain axis' where osteocytes, the cells within bone tissue, respond to mechanical stress by releasing specific protective factors into the bloodstream. These factors, including IL-1R2, APOL11a, and HSP70, reduce neuron loss and chronic inflammation in the brain. The findings suggest that modulating bone endocrine function through physical loading could be a viable therapeutic strategy for enhancing neurological repair after injury.

via Nature|

#bone-brain-axis #neuroregeneration #osteocytes

health3 months ago•12 min saved

Bones as a living signaling system that shapes your health

Bones are dynamic, living tissues that continually remodel in response to activity and hormones. They regulate minerals such as calcium and phosphate, support blood cell production in bone marrow, and emit signals that influence energy metabolism and other organs. Regular weight‑bearing exercise and adequate calcium and vitamin D help maintain bone strength, while aging and hormonal changes can raise osteoporosis risk. After fractures, bones heal through staged repair, underscoring bone health as a daily, integrative body function.

via The Conversation|

#bone-marrow #bone-remodeling #health