All articles tagged with #bone marrow
Ten women with advanced osteoporosis received autologous bone-marrow–derived mesenchymal cells engineered to improve bone-homing; after a single infusion, fracture rates dropped dramatically and stayed low for years, suggesting a potential one-time regenerative therapy, though the study was small, lacked a control group, and participants were on standard osteoporosis drugs, requiring larger randomized trials.
In 5xFAD mice and patients with Alzheimer's disease, bone marrow–derived myelopoiesis is impaired by a maladaptive type I interferon (IFN-I) response, altering monocyte development and peripheral monocyte phenotypes. Blocking IFN-I signaling or using IFNAR1-deficient bone marrow restores hematopoiesis, normalizes monocyte phenotypes, and increases monocyte-derived macrophage homing to the brain, mitigating disease pathology and highlighting a systemic contributor to AD progression.
Researchers at Trinity College Dublin and University College Dublin found that a common dietary yeast beta-glucan supplement reprograms early bone marrow immune cells to create trained immunity that strengthens anti-tumor responses against colorectal, skin, and breast cancers in obese mice and can reverse obesity-related immune memory defects after weight loss; since Wellmune is already food-grade, this could accelerate human trials to test dietary supplementation alongside cancer therapies.
Obese mice fed a yeast-derived beta-glucan supplement showed reprogrammed bone marrow stem cells that produced innate immune cells with enhanced anti-tumor activity, with effects lasting after weight loss; while promising, human trials are needed to determine applicability and safety.
Bones are dynamic, living tissues that continually remodel in response to activity and hormones. They regulate minerals such as calcium and phosphate, support blood cell production in bone marrow, and emit signals that influence energy metabolism and other organs. Regular weight‑bearing exercise and adequate calcium and vitamin D help maintain bone strength, while aging and hormonal changes can raise osteoporosis risk. After fractures, bones heal through staged repair, underscoring bone health as a daily, integrative body function.
A 17-year-old Fall River resident, Broeden Sabin, has been battling fatigue and pain and is seeking a bone marrow donor while undergoing a blood transplant this month, as his family appeals for potential donors.
During Artemis II’s lunar flyby, four tiny chips seeded with the astronauts’ bone marrow cells circled the Moon to study how deep-space conditions—like radiation and microgravity—affect human biology, part of NASA’s Avatar program using organ-on-a-chip devices to inform future space medicine.
A Leiden University–led study at the Neumark-Nord site near Leipzig shows Neanderthals operated “fat factories” about 125,000 years ago, deliberately selecting a lakeside location to extract marrow and render fat from hundreds of bones, demonstrating advanced planning and resource management far earlier than previously thought.
Researchers have discovered that glioblastoma not only damages the brain but also erodes the skull and disrupts the immune system by altering skull marrow, which may explain the failure of current treatments and highlight the need for systemic approaches.,
A recent study has found microplastics deep inside human bones, including bone marrow, and suggests they may harm health by impairing cell viability, accelerating aging, and potentially contributing to bone diseases like osteoporosis, prompting further research into their impact on bone health and fractures.
A study from NYU Langone Health found that restricted blood flow, caused by conditions like peripheral artery disease, accelerates cancer growth by aging the immune system and reprogramming bone marrow stem cells, leading to immune suppression and increased tumor progression.
Scientists have discovered that young blood serum, when combined with bone marrow cells, can activate anti-aging signals in human skin cells, potentially reversing signs of aging by promoting cell renewal and collagen production. This research, conducted using a 3D human skin model, highlights the role of specific proteins in this process and suggests promising avenues for future anti-aging therapies, although further testing in humans is needed.
Archaeologists discovered evidence of 125,000-year-old Neanderthal 'fat factories' at the Neumark-Nord site, showing they strategically harvested bone marrow from mammals, indicating advanced resource management and planning skills long before modern industrial practices.
Neanderthals in Germany 125,000 years ago developed a method to extract fat from animal bones, including marrow and grease, indicating advanced resource utilization that may have helped prevent nutritional deficiencies like protein poisoning, and suggesting they practiced innovative food processing behaviors earlier than previously thought.
A new study of International Space Station (ISS) astronauts suggests that fatty tissue inside bones helps replenish red blood cells and rebuild bone lost during space travel. The study examined 14 astronauts who spent at least six months on the ISS and found that the body uses fat in the bone marrow to replace red blood cells and increase bone density. This knowledge could lead to treatments for aging populations and individuals on Earth who are bedridden due to medical conditions. Understanding how to prevent anemia in space is crucial for future missions to the moon and Mars.