Tag

Neuroregeneration

All articles tagged with #neuroregeneration

science19 days ago•42 min saved

Tibial Compression Boosts Brain Recovery via Osteocyte Signaling

A new study in Nature Neuroscience demonstrates that mechanical compression of the tibia bone significantly improves survival and cognitive recovery in mice and pigs suffering from stroke or traumatic brain injury (TBI). The research identifies a direct 'bone-brain axis' where osteocytes, the cells within bone tissue, respond to mechanical stress by releasing specific protective factors into the bloodstream. These factors, including IL-1R2, APOL11a, and HSP70, reduce neuron loss and chronic inflammation in the brain. The findings suggest that modulating bone endocrine function through physical loading could be a viable therapeutic strategy for enhancing neurological repair after injury.

via Nature|

#bone-brain-axis #neuroregeneration #osteocytes

science1 month ago•5 min saved

Sea-Squirts Compound Reverses Age-Related Brain Decline in Mice

A multi-institution study fed aged mice plasmalogens derived from sea squirts, which led to improved learning in a memory task, more and healthier synapses, reduced brain inflammation, and even thicker hair, suggesting plasmalogens could support neuroregeneration and counter cognitive aging—though human applicability and safety remain to be tested.

via Science Daily|

#aging #gut-brain-axis #neuroregeneration

science1 month ago•171 min saved

Gel turns brain support cells into neurons, hinting at Alzheimer's therapy but still early-stage

Scientists report a polymer gel that carries a PTBP1-targeting antibody across the blood-brain barrier to astrocytes, converting them into neurons in cell cultures and brain organoids; in Alzheimer’s-model mice, this treatment correlated with more neurons, reduced inflammation, and improved memory in behavioral tests, though in vivo neuronal conversion remains unconfirmed and extensive safety and primate studies are still needed before any human trials.

via Live Science|

#alzheimers-disease #astrocytes #gel-therapy

science8 months ago•6 min saved

Dancing Peptides Cross the Blood-Brain Barrier to Repair Stroke Damage in Mice

Northwestern researchers developed an intravenously delivered supramolecular peptide therapy, IKVAV-PA, that crosses the blood-brain barrier after a stroke, accumulates at injury sites, and reduces tissue damage and inflammation in mice with a single post-reperfusion dose, without detectable organ toxicity. While no short-term behavioral improvement was seen, the approach shows promise as an adjunct to clot-reopening treatments and could extend to other brain injuries pending longer-term studies on cognitive and functional recovery.

via Indian Defence Review|

#blood-brain-barrier #ikvav-pa #nanomaterials

health11 months ago•2 min saved

Scientists Discover Old Drug Thiorphan as Potential Spinal Cord Regeneration Therapy

Researchers at UCSD have identified the existing drug Thiorphan as a potential treatment to regenerate nerve cells in the spinal cord, showing promising results in animal models and human neuron studies, which could lead to new therapies for paralysis in the future.

via Times of India|

#drug-repurposing #health #neuroregeneration

medical-research11 months ago•28 min saved

Bioinformatics Accelerates Development of Regenerative Therapies for Spinal Cord Injury

Researchers identified thiorphan as a promising drug to promote neural regeneration and functional recovery after spinal cord injury by using a bioinformatics-driven pipeline, in vitro and in vivo testing, and validation in primate and human neurons, showing its potential for clinical translation.

via Nature|

#drug-discovery #medical-research #neural-repair

health1 year ago•3 min saved

Stem Cell Therapy Promotes Brain Repair and Recovery Post-Stroke

Researchers at the University of Zurich have demonstrated that stem cell transplantation can reverse stroke damage by regenerating neurons and restoring motor functions in mice, paving the way for potential human therapies.

via ScienceDaily|

#brain-repair #clinical-trials #health

health1 year ago•6 min saved

Enzyme Blockade Reverses Parkinson’s Cell Damage in New Study

Scientists discovered that inhibiting the overactive enzyme LRRK2 in mice with a Parkinson's-related mutation can restore damaged brain cells, regrow cellular antennae called cilia, and improve dopamine signaling, suggesting a potential approach to reverse early Parkinson’s damage.

via SciTechDaily|

#cell-signaling #enzyme-inhibition #health