Tag

Peptidoglycan

All articles tagged with #peptidoglycan

science1 month ago•7 min saved

Worm Neurons Decode Bacterial Signals, Revealing a Gut-Brain Communication Code

MIT researchers identify the exact bacterial signals that activate the enteric neuron NSM in C. elegans: specific polysaccharides, including peptidoglycan from gram-positive bacteria, trigger neural activity via acid-sensing ion channels (ASICs) to regulate feeding, while the pathogenic pigment prodigiosin can suppress this signaling. The findings map a mechanistic, likely evolutionarily conserved gut-brain communication pathway with potential implications for targeted therapies in humans.

via Neuroscience News|

#asics #c-elegans #gut-brain-axis

science8 months ago•6 min saved

Gut Bacteria Could Influence Your Sleep Patterns

A study suggests that bacterial cell wall molecules like peptidoglycan are present in the brain and fluctuate with sleep cycles, supporting a new 'holobiont condition' model where sleep is regulated by interactions between the brain and microbiome, potentially influencing cognition, behavior, and evolution.

via Neuroscience News|

#evolution #gut-brain-axis #microbiome

science-and-technology2 years ago•3 min saved

"Breakthrough: Scientists Uncover Innovative Method to Attack Bacterial Cell Wall"

Researchers led by Martin Thanbichler have discovered a central regulator, DipM, that controls different classes of autolysins involved in bacterial cell wall remodeling. DipM interacts with multiple autolysins and a cell division factor, making it the first identified regulator that can control two classes of autolysins. Disruption of DipM leads to cell death, highlighting its critical role in cell shape maintenance and division. These findings may contribute to the development of new therapeutic strategies against bacterial infections by targeting multiple autolytic pathways simultaneously.

via News-Medical.Net|

#autolysins #bacterial-cell-wall #cell-division