Tumors Neutralize T Cells by Depleting Essential Reactive Oxygen Species
A study published in Science reveals that cancer cells actively suppress immune responses by releasing the antioxidant enzyme peroxiredoxin-1 (PRDX1). This enzyme neutralizes reactive oxygen species (ROS) in the tumor microenvironment, which T cells require to activate and attack tumors. By stripping the environment of ROS, tumors effectively 'smother' the immune system. The research, led by Oregon Health & Science University and the University of Cambridge, identifies PRDX1 as a new target for immunotherapy, suggesting that blocking this enzyme could restore T cell activity and improve treatment outcomes for resistant cancers.