All articles tagged with #rna structure
Researchers used a new cryo-electron microscopy protocol to visualize 76 distinct conformers of RNase P RNA, revealing that catalysis is regulated by dynamic structural ensembles and Mg2+ ion movements rather than a single static structure. The accessory protein rnpA shifts the equilibrium toward active states via allosteric effects, not by altering the local catalytic site.
Researchers mapped, at atomic resolution, a conserved cloverleaf RNA structure at the start of enterovirus genomes that recruits the 3CD protein to initiate replication. The sD stem-loop binds two 3C units, acting as a molecular switch between translation and replication, a feature conserved across poliovirus, coxsackievirus, rhinoviruses, and EV71. Because this RNA–protein interface is highly conserved, it offers a promising target for broad-spectrum antivirals that could disrupt replication across the enterovirus family.
Researchers have discovered a new class of virus-like lifeforms, called Obelisks, living inside the human body, particularly in saliva and the gut. These microscopic structures have no known structural similarities to any other biological agents and are prevalent in the human microbiome. They exist within bacteria and contain genetic codes for a new class of protein called Oblins, but their impact on humans remains unknown. This discovery may provide insights into how simple genetic molecules are linked to more complex ones.
Researchers are exploring the art of designing therapeutic mRNA molecules for vaccines and immunotherapies. They are investigating various factors that influence mRNA stability and translation efficiency, such as codon usage, RNA structure, and nucleotide modifications. By optimizing these parameters, scientists aim to enhance the effectiveness and safety of mRNA-based therapies. Deep learning models are also being developed to predict RNA secondary structure, aiding in the design process. Understanding the intricacies of mRNA design could lead to improved treatments for various diseases.