All articles tagged with #mrna stability
Scientists identified DHX29 as a key regulator that senses non-optimal codons during translation, binding to ribosomes decoding these codons and recruiting the GIGYF2•4EHP complex to suppress certain mRNAs. This reveals a second regulatory layer in the genetic code that links synonymous codon choice to gene expression and may influence development and disease.
Researchers at the University of Tokyo have developed non-toxic polymers that can stabilize and deliver mRNA into cells more effectively, potentially revolutionizing mRNA-based therapies. By fine-tuning the structure of the polymer molecules and attaching specific positively charged amino acid groups, the mRNA was stabilized and delivered into cultured human cells and live mouse cells with high efficiency. This breakthrough could lead to improved mRNA delivery technologies, innovative release strategies, and enhanced stability and efficacy in mRNA-based therapies for various treatments beyond infectious diseases.
Researchers are exploring the art of designing therapeutic mRNA molecules for vaccines and immunotherapies. They are investigating various factors that influence mRNA stability and translation efficiency, such as codon usage, RNA structure, and nucleotide modifications. By optimizing these parameters, scientists aim to enhance the effectiveness and safety of mRNA-based therapies. Deep learning models are also being developed to predict RNA secondary structure, aiding in the design process. Understanding the intricacies of mRNA design could lead to improved treatments for various diseases.