Tag

Schistosomiasis

All articles tagged with #schistosomiasis

Decades of pelvic pain finally explained by a tropical parasite
health2 months ago

Decades of pelvic pain finally explained by a tropical parasite

After more than 100 doctors over decades, Andy L.’s constant pelvic and perineal pain was finally explained by a rectal biopsy showing a granuloma and antibodies confirming urogenital schistosomiasis from a Tanzania trip decades earlier. Misdiagnoses—from Peyronie’s disease to psychosomatic explanations—gave way to the diagnosis, and praziquantel treatment lowered antibodies and eased symptoms, though eggs left in tissue can cause ongoing problems. He’s now raising awareness of this neglected tropical disease that mostly affects Africa.

"Novel Vaccine Approach Targets Widespread Parasite Infection"
health-science2 years ago

"Novel Vaccine Approach Targets Widespread Parasite Infection"

Scientists in Brazil have used a radical vaccine strategy involving phage display to identify potential vaccine targets for schistosomiasis, a neglected tropical disease affecting millions worldwide. By analyzing proteins of the Schistosoma parasite, the researchers have identified key proteins driving the immune response to the infection, opening up promising prospects for vaccine development. While early results in mice are encouraging, the track record of schistosomiasis vaccines is challenging, with most candidates failing to elicit a strong immune response or protect against the disease. Nonetheless, this study provides a wealth of new candidates for further exploration in the quest for an effective vaccine.

Immune system mechanism fights parasitic infection.
health3 years ago

Immune system mechanism fights parasitic infection.

Penn State immunology researchers have discovered that type I interferon, a protein that is important for the body's defense against viruses, plays a critical role in suppressing inflammation in mice infected with the schistosome parasite. Schistosomiasis is a parasitic disease responsible for more than 250 million human infections worldwide. The discovery may lead to effective therapies for those suffering from schistosomiasis, second only to malaria as the most prevalent parasitic disease globally.