Tag

Targeted Treatments

All articles tagged with #targeted treatments

"Uncovering the Gender Disparities in Chronic Pain Perception and Treatment"
health-and-medicine2 years ago

"Uncovering the Gender Disparities in Chronic Pain Perception and Treatment"

A University of Alberta research team has discovered differences in the development and resolution of chronic pain in male and female mice, shedding light on potential pathways for targeted treatments in humans. The study found that female mice were more sensitive to the effects of immune cells and identified an X chromosome-linked receptor critical for resolving inflammation in both sexes. The research suggests that chronic pain is linked to the function of the immune system and may require sex-specific treatments, with potential implications for future therapies.

Unraveling Alzheimer's: Genetics, Mutations, and Neuroinflammation
health2 years ago

Unraveling Alzheimer's: Genetics, Mutations, and Neuroinflammation

Researchers have used single nucleus RNA sequencing to analyze genetic risks in microglia and astrocytes, two types of brain cells, and have identified their distinct roles in the progression of Alzheimer's disease (AD). Astrocytes were found to impact early stages of the disease, such as amyloid-β buildup, while microglia influenced later stages, including plaque and tau tangle accumulation and cognitive decline. These findings provide crucial insights for developing targeted therapies that specifically target the genetic risks associated with different cell types in the brain.