Tag

Tocilizumab

All articles tagged with #tocilizumab

health1 hour ago•4 min saved

Inflammation-Targeted Therapy Shows Early Promise for Hard-to-Treat Depression

In a small randomized trial, the IL-6 blocker tocilizumab—an existing anti-inflammatory drug—reduced depression symptoms and improved fatigue and quality of life in some people with treatment-resistant depression. Remission was higher in the treatment group (54%) versus placebo (31%), with an estimated number needed to treat of 5, but the study’s small size means results are preliminary and larger phase III trials are needed to confirm efficacy.

via SciTechDaily|

#depression #health #il-6

health-and-medicine4 days ago•6 min saved

Inflammation-Driven Depression Gets a New Target in Small Trial

A small randomized trial (n=30) tested tocilizumab, an IL-6 blocker used for inflammatory diseases, in treatment-resistant depression with signs of inflammation. Participants receiving the drug showed greater improvement in depression, fatigue, anxiety, and quality of life, with a higher remission rate (54% vs. 31%) and an NNT of 5, suggesting a potential immune-based approach to treating depression, though larger phase III trials are needed to confirm efficacy and safety.

via ScienceDaily|

#depression #health-and-medicine #il-6

health7 days ago•5 min saved

IL-6 blocker offers early hope for hard-to-treat depression

A four-week proof-of-concept trial in 30 adults with major depressive disorder and signs of inflammation tested the IL-6 receptor blocker tocilizumab. Treated participants showed greater improvements in depressive symptoms, fatigue, anxiety, and quality of life than placebo, with remission rates around 54% vs 31%, but the study was not powered for statistical significance. The researchers highlighted that those with higher baseline inflammation tended to respond best, suggesting inflammation-targeted therapies merit larger, longer trials. No notable adverse effects were reported.

via ScienceAlert|

#clinical-trial #depression #health

health12 days ago•2 min saved

Anti-inflammatory drug shows potential for hard-to-treat depression in early trial

A small Bristol randomized trial suggests the anti-inflammatory drug tocilizumab, which blocks IL-6R, may benefit people with treatment-resistant depression. Those given the drug showed greater improvement across measures and higher remission rates (54% vs 31%) with a number needed to treat of 5, though the small sample size means results are preliminary and require confirmation in larger studies; this points to a potential new, tailored immunotherapy approach for patients not responding to standard antidepressants.

via The Guardian|

#clinical-trial #depression #health