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Il 6

All articles tagged with #il 6

Inflammation-Driven Depression Gets a New Target in Small Trial
health-and-medicine2 days ago

Inflammation-Driven Depression Gets a New Target in Small Trial

A small randomized trial (n=30) tested tocilizumab, an IL-6 blocker used for inflammatory diseases, in treatment-resistant depression with signs of inflammation. Participants receiving the drug showed greater improvement in depression, fatigue, anxiety, and quality of life, with a higher remission rate (54% vs. 31%) and an NNT of 5, suggesting a potential immune-based approach to treating depression, though larger phase III trials are needed to confirm efficacy and safety.

via ScienceDaily|
#depression#health-and-medicine#il-6
IL-6 blocker offers early hope for hard-to-treat depression
health5 days ago

IL-6 blocker offers early hope for hard-to-treat depression

A four-week proof-of-concept trial in 30 adults with major depressive disorder and signs of inflammation tested the IL-6 receptor blocker tocilizumab. Treated participants showed greater improvements in depressive symptoms, fatigue, anxiety, and quality of life than placebo, with remission rates around 54% vs 31%, but the study was not powered for statistical significance. The researchers highlighted that those with higher baseline inflammation tended to respond best, suggesting inflammation-targeted therapies merit larger, longer trials. No notable adverse effects were reported.

via ScienceAlert|
#clinical-trial#depression#health