Tag

Trained Immunity

All articles tagged with #trained immunity

health-and-medicine2 days ago•6 min saved

Dietary Yeast Trains Immune System to Fight Cancer in Mice

Researchers at Trinity College Dublin and University College Dublin found that a common dietary yeast beta-glucan supplement reprograms early bone marrow immune cells to create trained immunity that strengthens anti-tumor responses against colorectal, skin, and breast cancers in obese mice and can reverse obesity-related immune memory defects after weight loss; since Wellmune is already food-grade, this could accelerate human trials to test dietary supplementation alongside cancer therapies.

via Science Daily|

#bone-marrow #cancer-immunology #health-and-medicine

science1 month ago•5 min saved

Yeast-Derived Supplement Reprograms Immune System to Fight Cancer in Obese Mice

Obese mice fed a yeast-derived beta-glucan supplement showed reprogrammed bone marrow stem cells that produced innate immune cells with enhanced anti-tumor activity, with effects lasting after weight loss; while promising, human trials are needed to determine applicability and safety.

via SciTechDaily|

#bone-marrow #cancer #obesity

science1 month ago•6 min saved

BCG vaccine may reprogram brain immunity and amyloid handling in aging

A small year-long open-label study suggests the Bacillus Calmette-Guérin (BCG) vaccine can boost immune cell responsiveness in blood and cerebrospinal fluid without triggering sustained brain inflammation. In older adults without Alzheimer’s pathology, beta-amyloid shifted from CSF to the blood, hinting at improved clearance from the brain, while those with existing biomarkers did not show the same changes. The findings offer a potential mechanism linking BCG to lower Alzheimer’s risk but are preliminary, as the study lacked a placebo group and involved only 23 participants, requiring larger randomized trials to confirm any clinical benefit.

via Medical News Today|

#alzheimers-disease #bcg-vaccine #beta-amyloid

health3 months ago•7 min saved

Vaccines Might Lower Dementia Risk Through Trained Immunity, Researchers Propose

A growing body of evidence links routine vaccines (including flu, shingles, RSV, Tdap, pneumococcal, hepatitis A/B, and typhoid) with lower dementia risk. A leading hypothesis is that vaccines train the innate immune system via epigenetic changes, enabling stronger, non-specific responses that may reduce brain inflammation and slow cognitive decline. While data from BCG studies and population analyses support the idea, the exact mechanisms remain unproven and require more research. If validated, this could broaden understanding of vaccine benefits beyond targeted pathogen protection.

via Ars Technica|

#dementia #epigenetics #health