Tag

Tyk2

All articles tagged with #tyk2

Ancient DNA Reveals Humans Still Evolving Through Natural Selection
science4 days ago

Ancient DNA Reveals Humans Still Evolving Through Natural Selection

A large-scale study of 15,836 ancient human remains finds 479 genetic variants that appear to have been favored by natural selection in the past 10,000 years, with thousands more likely affected. Notably, a mutation linked to celiac disease emerged about 4,000 years ago and rose in frequency, while variants associated with smoking have become rarer in Europe. Other changes include TYK2-related immune variants and shifts around blood-type genetics, with signals detected in 44 of 563 traits. The findings suggest humans are evolving in ways that are not fully explained by culture or technology, though the exact forces remain unclear.

New Study Suggests Enzyme Blockade Could Reverse Alzheimer's
health1 year ago

New Study Suggests Enzyme Blockade Could Reverse Alzheimer's

A study published in Nature Neuroscience has identified the enzyme tyrosine kinase 2 (TYK2) as a potential target for treating Alzheimer's disease. In genetically modified mice with excessive tau protein, blocking TYK2 reduced harmful tau buildup and showed signs of neuronal recovery. This discovery could lead to new drug development, although further research is needed to confirm these findings in humans.