All articles tagged with #celiac disease
A BuzzFeed/Yahoo Health piece compiles 25 firsthand accounts of illnesses that are often dismissed as “just pain,” highlighting conditions from IBS with anxiety and celiac disease to chronic migraines, endometriosis, chronic fatigue syndrome and Ehlers-Danlos, showing how these conditions profoundly disrupt daily life and underscoring the need for validation, better care, and support for the people living with them.
Jennifer Esposito shared that years of undiagnosed illness left her severely ill and deeply depressed during the early part of her career, culminating in an involuntary psychiatric hold after doctors failed to diagnose her. She described misdiagnoses, escalating symptoms (including hair and nail loss and a tooth falling out), and a low point that nearly led to self-harm, before finally being diagnosed with celiac disease and beginning a long recovery. She emphasized that healing takes time and highlighted the broader issue of medical gaslighting.
Actress Jennifer Esposito recounts years of debilitating, misdiagnosed symptoms and severe depression that culminated in a psychiatric ward stay before doctors diagnosed her with celiac disease; after adopting a gluten-free diet and pursuing gut-health recovery, she’s now healthier, no longer has panic attacks, and hopes to help others facing similar health battles.
Jennifer Esposito recounts years of misdiagnoses and severe health problems—including liver failure and a psych ward stay—before doctors diagnosed her with celiac disease; since adopting a strict gluten-free diet, her symptoms eased, her life improved, and she now advocates gut health and a calmer pace of life.
A comprehensive review of 100+ studies maps how genetic risk, the TG2 enzyme, immune cells (including intraepithelial lymphocytes), stromal cell signals, and gut bacteria interact to amplify gluten-triggered immune damage to the gut lining. This multi-factor cascade helps explain why only some genetically predisposed people develop celiac disease and could guide future therapies beyond a gluten-free diet.
Argenx announced a $2.2 billion acquisition of Forte Biosciences to obtain FB102, a phase 1b anti-CD122 antibody that showed a 29.6% improvement in facial vitiligo and is set for phase 2 readouts in celiac disease later this year. The deal broadens Argenx’s autoimmune portfolio beyond Vyvgart and supports its Vision 2030 plan to reach 50,000 patients across 10 indications, financed by a strong cash position of about $5.2 billion. Forte shareholders will receive $77 per share.
The article discusses how gluten-related conditions, especially celiac disease, may affect sleep via GI symptoms, systemic inflammation, and nutrient absorption, with mixed evidence on whether a gluten-free diet improves sleep. It notes that sleep quality can improve for some individuals on a gluten-free diet if calories and nutrients are adequate, but improvements are gradual and influenced by factors like stress or iron/magnesium/B vitamin status. Clinicians are advised to consider sleep hygiene and dietary factors when advising patients on gluten-related issues, while recognizing that more research is needed on the gluten-sleep relationship.
A Harvard Medical School study of ancient DNA from about 16,000 people over 10,000 years finds that the genetic variants behind red hair and fair skin may confer immune benefits (including potential HIV resistance and leprosy resistance) and lower arthritis risk, but also raise the risk of Crohn's disease and celiac disease due to gluten sensitivity, suggesting a trade‑off shaped by ancient selection and the spread of wheat farming.
Harvard Medical School researchers analyzed 10,000 years of DNA from about 16,000 people and found that the genetic variants behind red hair and fair skin were favored by natural selection, with potential immune benefits (including HIV resistance and leprosy resistance) and lower risk of certain conditions, but these same genes may raise the risk of gluten-related autoimmune diseases such as Crohn’s disease and celiac disease, possibly linked to the advent of wheat farming; vitamin D production advantages were noted in earlier work.
A large-scale study of 15,836 ancient human remains finds 479 genetic variants that appear to have been favored by natural selection in the past 10,000 years, with thousands more likely affected. Notably, a mutation linked to celiac disease emerged about 4,000 years ago and rose in frequency, while variants associated with smoking have become rarer in Europe. Other changes include TYK2-related immune variants and shifts around blood-type genetics, with signals detected in 44 of 563 traits. The findings suggest humans are evolving in ways that are not fully explained by culture or technology, though the exact forces remain unclear.
Researchers have identified the role of gut lining cells in the initiation of gluten reactions in celiac disease, a breakthrough that could lead to new treatments for this autoimmune disorder triggered by gluten ingestion, which damages the small intestine and causes various health issues.
While gluten-free diets are essential for celiac disease patients and can help those with gluten sensitivity, current research indicates that for people without these conditions, avoiding gluten offers no significant health benefits and may lead to less nutritious eating habits. The rise in popularity is driven by social media and celebrity endorsements, but experts warn that unnecessary gluten avoidance could result in missing out on vital nutrients and consuming more processed foods.
Scientists have identified the crucial role of gut lining cells in the initiation of celiac disease, revealing new potential targets for therapies beyond just avoiding gluten, which could improve treatment options for those affected.
Silent celiac is an asymptomatic form of celiac disease where individuals have intestinal damage without obvious symptoms, often diagnosed through blood tests and biopsies, and managed effectively with a strict gluten-free diet to prevent long-term health complications.
Scientists have developed a promising approach using engineered regulatory T cells as an 'inverse vaccine' to potentially treat celiac disease, showing success in mice by reducing immune reactions to gluten, though further research is needed.