All articles tagged with #celiac disease
A Harvard Medical School study of ancient DNA from about 16,000 people over 10,000 years finds that the genetic variants behind red hair and fair skin may confer immune benefits (including potential HIV resistance and leprosy resistance) and lower arthritis risk, but also raise the risk of Crohn's disease and celiac disease due to gluten sensitivity, suggesting a trade‑off shaped by ancient selection and the spread of wheat farming.
Harvard Medical School researchers analyzed 10,000 years of DNA from about 16,000 people and found that the genetic variants behind red hair and fair skin were favored by natural selection, with potential immune benefits (including HIV resistance and leprosy resistance) and lower risk of certain conditions, but these same genes may raise the risk of gluten-related autoimmune diseases such as Crohn’s disease and celiac disease, possibly linked to the advent of wheat farming; vitamin D production advantages were noted in earlier work.
A large-scale study of 15,836 ancient human remains finds 479 genetic variants that appear to have been favored by natural selection in the past 10,000 years, with thousands more likely affected. Notably, a mutation linked to celiac disease emerged about 4,000 years ago and rose in frequency, while variants associated with smoking have become rarer in Europe. Other changes include TYK2-related immune variants and shifts around blood-type genetics, with signals detected in 44 of 563 traits. The findings suggest humans are evolving in ways that are not fully explained by culture or technology, though the exact forces remain unclear.
Researchers have identified the role of gut lining cells in the initiation of gluten reactions in celiac disease, a breakthrough that could lead to new treatments for this autoimmune disorder triggered by gluten ingestion, which damages the small intestine and causes various health issues.
While gluten-free diets are essential for celiac disease patients and can help those with gluten sensitivity, current research indicates that for people without these conditions, avoiding gluten offers no significant health benefits and may lead to less nutritious eating habits. The rise in popularity is driven by social media and celebrity endorsements, but experts warn that unnecessary gluten avoidance could result in missing out on vital nutrients and consuming more processed foods.
Scientists have identified the crucial role of gut lining cells in the initiation of celiac disease, revealing new potential targets for therapies beyond just avoiding gluten, which could improve treatment options for those affected.
Silent celiac is an asymptomatic form of celiac disease where individuals have intestinal damage without obvious symptoms, often diagnosed through blood tests and biopsies, and managed effectively with a strict gluten-free diet to prevent long-term health complications.
Scientists have developed a promising approach using engineered regulatory T cells as an 'inverse vaccine' to potentially treat celiac disease, showing success in mice by reducing immune reactions to gluten, though further research is needed.
The gluten-free diet trend has gained popularity, but it's important to remember that celiac disease affects approximately 3 million Americans, requiring strict avoidance of gluten. Additionally, more than 18 million Americans have nonceliac gluten sensitivity, and others have wheat allergies. While some people choose to avoid gluten for non-disease-related reasons, experts emphasize that the majority of individuals can digest gluten without issues. It's crucial to be mindful of the nutritional quality and cost of gluten-free products, as well as to avoid assuming that all gluten-free foods are inherently healthy.
For those with gluten sensitivity, sourdough bread may be easier to digest due to the fermentation process, which pre-digests the gluten. However, it's important to ensure that the sourdough is made with a traditional starter and not fast-rising baker's yeast, as the latter won't provide the same gut-friendly benefits. Making sourdough at home allows for experimentation with proofing times to find the most digestible option.
For those with gluten sensitivity, sourdough bread may be easier to digest due to the fermentation process, which pre-digests the gluten. However, it's important to ensure that the sourdough is made with a traditional starter and not fast-rising baker's yeast, as the latter won't provide the same gut-friendly benefits. Experimenting with different proofing times when making sourdough at home can help determine the bread's digestibility for individual sensitivities.
While a gluten-free diet is essential for those with Celiac disease, it may not be beneficial for everyone. Research suggests it could help lower thyroid antibody levels and alleviate symptoms of irritable bowel syndrome for some individuals, but the results are inconclusive. Additionally, gluten-free diets can be expensive and may lead to nutritional deficits if not carefully planned, making it important for those considering this diet to seek guidance from a healthcare professional.
The gluten-free lifestyle has become popular, but it's important to understand the implications before making the switch. Celiac disease, non-celiac gluten sensitivity, wheat allergy, and observing symptom patterns are key factors to consider. While going gluten-free may offer benefits like improved digestive health and energy levels, it can also lead to nutrient deficiencies, increased expenses, limited food choices, dining challenges, social and emotional impacts, hidden gluten exposure, and potential weight gain. Consulting with healthcare professionals is crucial before making significant dietary changes.
Gluten is a protein found in grains like wheat, barley, and rye, as well as triticale. While gluten is essential for the structure and texture of foods, it only harms individuals with celiac disease or gluten sensitivity. For those without these conditions, excluding gluten from their diet can be detrimental as it eliminates foods with health benefits like whole grains. The rise in gluten-free diets may be due to the increased availability of gluten-free products for individuals with celiac disease, leading to misconceptions about the healthiness of gluten.
There is an increased risk of restless legs syndrome (RLS) among people with celiac disease, often due to iron deficiency. Iron deficiency is frequently found in individuals with RLS and can worsen the symptoms. Treatment with iron supplementation can potentially improve nighttime symptoms. Regarding the use of Estrace vaginal cream, it is considered safe and beneficial for maintaining healthy vaginal tissue when used topically. However, caution should be exercised in individuals with a personal history of estrogen-sensitive tumors, such as endometrial or certain breast cancers, and a discussion with the patient's oncologist is recommended.