
Mobile resistance gene drives US rise of deadly hospital infections
A CDC report finds NDM-carrying CRE infections surged 461% in the U.S. from 2019–2023; the NDM gene is mobile on plasmids and can jump between bacteria, fueling hospital outbreaks across multiple species and complicating treatment. Wastewater data show community spread with regional patterns and links to socioeconomic factors; while aztreonam-avibactam offers a new option, there is no endgame, underscoring the need for better testing, surveillance, and stewardship.












