Tau's mitochondrial twist fuels new Alzheimer's drug strategy

Stanford researchers found tau can trigger reverse electron transport in mitochondria, generating reactive oxygen species and cellular stress; blocking this retrograde flow reversed harmful effects and improved learning/memory in flies and mice, suggesting a novel therapeutic angle for Alzheimer’s. Early human cell/tissue data support the idea, and two authors have started a biotech startup to pursue further validation, though results in people remain unproven.