Cognitive Flexibility May Act as Early Hint for Alzheimer’s, Study Finds
TL;DR Summary
A Nature Communications study using 5xFAD mice shows cognitive flexibility is impaired before memory deficits, linked to hyperactivity in the medial prefrontal cortex; silencing overactive neurons reduces amyloid-beta accumulation and partially restores flexibility, suggesting a potential route to earlier Alzheimer’s diagnosis.
Topics:health#alzheimers-disease#amyloid-beta#cognitive-flexibility#early-diagnosis#prefrontal-cortex#science
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