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Edge-Guard Macrophages Attack Live Melanoma Cells, Poised to Boost Immunotherapy

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Source: ScienceAlert
Edge-Guard Macrophages Attack Live Melanoma Cells, Poised to Boost Immunotherapy
Photo: ScienceAlert
TL;DR

Researchers using real-time imaging show CD169-positive macrophages at the edges of melanoma tumors actively engulf live cancer cells and help signal the immune system, constraining tumor growth even without T cells or B cells. Similar macrophages are found in human samples, suggesting these cells could be mobilized to convert cold tumors to hot and broaden the reach of immunotherapies like checkpoint inhibitors.

Topics:healthscience#cd169#immunotherapy#macrophages#melanoma#science#tumor-microenvironment
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  3. Researchers identify innate immune barrier against melanoma  BioWorld News
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