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Ibd

All articles tagged with #ibd

Colon Chip uncovers fibroblasts as key drivers of IBD and early cancer signals
science1 day ago

Colon Chip uncovers fibroblasts as key drivers of IBD and early cancer signals

Researchers created a patient-derived Colon Chip that replicates many inflammatory bowel disease features in vitro, revealing that fibroblasts actively drive inflammation and barrier breakdown. When healthy tissue is grown with diseased fibroblasts, it adopts IBD-like traits; adding mechanical stretch and pregnancy-related hormones further amplifies inflammatory and fibrotic responses. The model also showed diseased chips exhibit stronger cancer-associated molecular changes after exposure to a carcinogen, suggesting fibroblasts play a central role in cancer susceptibility. This human, organ-on-a-chip platform offers a more faithful way to study IBD progression and the earliest steps of cancer than traditional cell cultures or animal models.

via ScienceAlert|
#cancer-risk#colon-chip#fibroblasts
Genetic Variant Tied to IBD Drives Disease via IL-10–Neutralizing Antibodies
science1 month ago

Genetic Variant Tied to IBD Drives Disease via IL-10–Neutralizing Antibodies

A UK-Denmark study links the IBD-associated HLA-DRB1*01:03 variant to antibodies that neutralize interleukin-10, removing its anti-inflammatory brake and driving disease in about 3.5% of patients (2.5% Crohn’s, 4.4% ulcerative colitis); the finding, published in The New England Journal of Medicine, points to targeted therapies for this subgroup.

via ScienceAlert|
#autoantibodies#genetics#hla-drb10103
Single-cell atlas links IBD risk to cell-type specific gene regulation
science1 month ago

Single-cell atlas links IBD risk to cell-type specific gene regulation

Researchers built IBDverse, the largest single-cell eQTL atlas for inflammatory bowel disease, mapping cis-eQTL effects across blood and gut tissues in about 400 individuals to link genetic risk to specific cell types. They find cell-type eQTLs are more distal, enhancer-rich, and far more likely to colocalize with IBD GWAS signals than bulk-tissue eQTLs, nominating effector genes such as MAML2 and ZMIZ1 in dendritic cells and MYC and RASGRP1 in colonocytes. Notch pathway regulators in dendritic cells and Wnt-driven epithelial renewal in colonocytes emerge as key mechanisms, tying regulatory variation to barrier dysfunction and inflammation. The study also highlights therapeutic angles—including PRKCB inhibitors and targets like ITGA4/JAK2—and provides a framework for interpreting GWAS loci via cell-type–resolved eQTL mapping in complex diseases.

via Nature|
#eqtl#gwas#ibd
Vitamin D's emerging links to diabetes risk, brain biomarkers, and gut immunity
health2 months ago

Vitamin D's emerging links to diabetes risk, brain biomarkers, and gut immunity

New studies suggest vitamin D may influence several chronic diseases: high-dose vitamin D (4,000 IU/day) reduced progression from prediabetes to type 2 diabetes in people with AC/CC variants of the vitamin D receptor gene, but had no benefit for others and excess doses carry risks; higher vitamin D levels in midlife were linked to lower tau protein, a biomarker for Alzheimer's, years later but not with beta-amyloid and the study had limitations; in inflammatory bowel disease, 12 weeks of vitamin D supplementation reduced gut inflammation and promoted a more balanced immune response (increasing IgA, decreasing IgG), indicating potential as an adjunct therapy. Overall, vitamin D is not a cure-all and results are preliminary, needing replication and careful medical supervision.

via Medical News Today|
#alzheimers-disease#diabetes#health
Vitamin D Boost May Help Reset Immune Response in Some IBD Patients
health3 months ago

Vitamin D Boost May Help Reset Immune Response in Some IBD Patients

A study in Cell Reports Medicine followed 48 adults with inflammatory bowel disease and low vitamin D, giving 50,000 IU of vitamin D weekly for 12 weeks. After three months, many participants reported better quality of life, reduced disease activity, and lower inflammatory markers in stool, with the immune system shifting toward greater tolerance of gut bacteria and a more favorable gut microbiome. The findings suggest vitamin D can support immune and gut health in IBD and possibly other autoimmune conditions, though it’s not a universal cure and dosing should be guided by a clinician through regular blood work and tailored advice.

via AOL.com|
#cell-reports-medicine#gut-microbiome#health
Stool biomarkers and meat intake may forewarn IBD flares, study suggests
health5 months ago

Stool biomarkers and meat intake may forewarn IBD flares, study suggests

A large UK study (PREdiCCt) of over 2,600 people with inflammatory bowel disease found that higher baseline fecal calprotectin, a noninvasive stool marker of gut inflammation, strongly predicted future flares even when patients were symptom-free—UC patients with elevated calprotectin faced about a 34% objective flare risk within 2 years vs ~11% with low levels. Habitual meat intake was linked to nearly double the risk of ulcerative colitis flares, while other dietary factors showed no consistent associations; there was no such meat-flare link for Crohn’s disease. The results point to a potential for biomarker- and diet‑guided, personalized IBD management, using stool tests plus dietary data to forecast relapses months ahead. However, the study is observational and cannot prove causation, and local validation may be needed before widespread adoption.

via AOL.com|
#crohns-disease#fecal-calprotectin#health
Understanding the Fundamentals of Inflammatory Bowel Disease
health10 months ago

Understanding the Fundamentals of Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), affecting up to 3.1 million adults in the U.S., is a chronic condition where the immune system attacks the intestines, causing inflammation and damage. Diagnosis involves medical history, physical exams, lab tests, and imaging like endoscopy or MRI. IBD differs from irritable bowel syndrome (IBS), which has similar symptoms but no underlying disease. Managing IBD requires a team approach to find effective medication and lifestyle strategies to prevent flare-ups and address related health issues.

via Lawrence Journal-World|
#crohns-disease#diagnosis#health
New Molecule Found to Heal Gut and Inhibit Cancer Growth
science-and-health1 year ago

New Molecule Found to Heal Gut and Inhibit Cancer Growth

Researchers at Karolinska Institutet have discovered a molecule that promotes intestinal healing and suppresses colorectal cancer growth by activating the Liver X receptor. This finding, published in Nature, could lead to new treatments for inflammatory bowel disease (IBD) and cancer, addressing the need for alternatives to current therapies that often fail to help patients. The study highlights the potential of this molecule to treat chronic bowel disorders resulting from cancer therapies.

via SciTechDaily|
#cancer#ibd#intestinal-healing
Vagus Nerve Stimulation: A New Approach to Combat IBD Inflammation
health1 year ago

Vagus Nerve Stimulation: A New Approach to Combat IBD Inflammation

Researchers at Duke University have found that stimulating the vagus nerve can reduce gut inflammation in inflammatory bowel disease (IBD) by affecting SUMOylation, a process involved in immune response. This approach, which has shown promising results in mice, could lead to new therapies targeting inflammation directly, offering hope for the growing number of IBD patients worldwide. The study highlights the potential of bioelectronic medicine in managing chronic inflammatory conditions.

via Neuroscience News|
#bioelectronic-medicine#health#ibd
Decoding IBD and IBS: Understanding the Differences and Similarities.
health3 years ago

Decoding IBD and IBS: Understanding the Differences and Similarities.

IBS and IBD can cause similar digestive symptoms, but they are different conditions. IBD is a disease that causes inflammation in the digestive system and other parts of the body, while IBS is a disorder of gut-brain interaction. Both conditions have different causes, symptoms, and treatments. IBD can lead to serious complications, including extraintestinal manifestations, while IBS is not a risk factor for cancer. Treatment for IBS and IBD includes medication, diet, and lifestyle changes.

via Verywell Health|
#digestive-health#health#ibd
DNA test reveals half-sisters with shared bowel disease.
health3 years ago

DNA test reveals half-sisters with shared bowel disease.

Four strangers who took at-home DNA tests found out they were half-sisters from the same sperm donor and all suffer from ulcerative colitis, a chronic inflammation of the gastrointestinal tract. They became friends and shared medical advice and support. Doctors say there is a genetic connection with IBD, but studies show close to 80% of patients don't have a close relative with the disease.

via CBS Philly|
#chronic-inflammation#dna-test#health