Immune Switch Could Slow Aging, Study Suggests

A Science study links aging to tissue-resident macrophages that accumulate the EP2 receptor, which hampers clearance of senescent neutrophils and fuels chronic inflammation. In mice lacking EP2, many aging-related blood proteins stayed younger, with notable improvements tied to the liver, suggesting EP2 as a potential target to slow aging. However, targeting EP2 without disrupting prostaglandin E2’s other roles is challenging, so researchers stress the need for approaches that preserve other functions while slowing aging.