Lifespan ceiling? Mutations may cap human life around 150–190 years, study finds

A Skolkovo Institute study in NPJ Aging uses a mathematical model to estimate a hard human lifespan limit if only DNA mutations remain as aging causes; average life is projected at about 146–194 years, with some potentially over 550. The cap would come from irreversible damage to the heart and brain, while other organs renew. The model is simplified and doesn’t account for organ interactions, but it offers a starting point toward a broader aging theory; experts note ageing could also be driven by cellular programming rather than wear and tear.