Safe drug reverses Alzheimer's markers in mice
TL;DR Summary
A drug called KCL-286, already proven safe in Phase 1 trials, improved DNA repair and reduced brain inflammation in Alzheimer's-model mice by boosting BRCA1 and calming microglia, suggesting a potential disease-modifying therapy that could move faster to human testing due to existing safety data.
- A Human-Safe Drug Reduces Multiple Signs of Alzheimer's in Mice ScienceAlert
- Could an investigational drug that targets DNA damage help treat Alzheimer’s disease? WebWire
- New drug slows Alzheimer’s disease in mice Futurity
- KCL-286 targets multiple Alzheimer’s pathways in preclinical study Drug Target Review
- Spinal Cord Injury Drug Shows Promise for Alzheimer’s Disease Technology Networks
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