ER Glutathione Regulator Proofreads Protein Folding

Rockefeller University researchers identify SLC33A1 as the transporter that exports oxidized glutathione (GSSG) into the endoplasmic reticulum to sustain an oxidized environment essential for correct protein folding; disruptions can cause protein misfolding linked to neurodegeneration and cancer, and inhibiting SLC33A1 could offer new therapeutic avenues.