All articles tagged with #endoplasmic reticulum
Rockefeller University researchers identify SLC33A1 as the transporter that exports oxidized glutathione (GSSG) into the endoplasmic reticulum to sustain an oxidized environment essential for correct protein folding; disruptions can cause protein misfolding linked to neurodegeneration and cancer, and inhibiting SLC33A1 could offer new therapeutic avenues.
Researchers studying aging in Caenorhabditis elegans found that aging promotes remodeling of the endoplasmic reticulum via ER-phagy, with rough ER declining while smooth ER changes are modest; this reorganization may affect protein homeostasis and aging, and could point to new drug targets for age-related diseases.
Scientists have identified SLC35B1 as the main transporter of ATP into the endoplasmic reticulum, providing structural insights that could lead to targeted therapies for diseases related to ER stress, such as diabetes and cancer.