Tag

Amylin

All articles tagged with #amylin

Novo Nordisk reports 25% weight loss for CagriSema in women
health-and-pharma2 hours ago

Novo Nordisk reports 25% weight loss for CagriSema in women

Novo Nordisk released new post-trial data showing its experimental combination drug CagriSema achieved an average 25% weight loss in women at 68 weeks. The results, based on an ideal adherence scenario, suggest the drug may outperform its current blockbuster, Wegovy, particularly for women across various menopausal stages. While the data supports efficacy, Wall Street remains cautious due to previous trial disappointments, though analysts project significant future sales.

Amylin and Triple-Agonist Trials Signal Next Wave in Obesity Treatment
health-and-science18 days ago

Amylin and Triple-Agonist Trials Signal Next Wave in Obesity Treatment

Eli Lilly and Novo Nordisk are advancing next-generation obesity treatments targeting the amylin pathway and multiple hormone receptors. Lilly’s Phase 2 trial showed its amylin drug eloralintide, combined with tirzepatide, achieved 23.3% weight loss, though side effects caused higher discontinuation rates. Meanwhile, Lilly’s triple-agonist retatrutide reached a Phase 3 milestone, with 12mg doses yielding 18.8% weight loss and improved metabolic markers in diabetic patients. Novo is preparing to launch its amylin-based CagriSema next year. These developments aim to address patients who do not respond adequately to current GLP-1 therapies, expanding treatment options through multi-pathway approaches.

Lilly's amylin-tirzepatide combo hits 23% weight loss in Phase 2 trial
health-and-science20 days ago

Lilly's amylin-tirzepatide combo hits 23% weight loss in Phase 2 trial

Eli Lilly reported that its experimental combination of the amylin-targeting drug eloralintide and its existing GLP-1/GIP drug tirzepatide produced superior weight loss in a mid-stage trial. Patients with obesity and Type 2 diabetes lost up to 23.3% of their body weight over 48 weeks, outperforming tirzepatide alone. While the results are promising, higher discontinuation rates due to side effects raised questions about tolerability. Lilly plans to advance the therapy to Phase 3 trials by the end of 2026.