Tag

Broadly Neutralizing Antibodies

All articles tagged with #broadly neutralizing antibodies

science21 days ago•13 min saved

Germline-targeted HIV vaccine sparks broad antibody response in primates

A germline-targeting, adjuvanted HIV vaccine administered to outbred nonhuman primates elicited bnAb-class memory B cells and serum neutralizing activity against diverse HIV isolates. bnAb lineages formed in >50% of animals with up to 67% neutralization breadth, and serum bnAb activity appeared in 44% of subjects, with some titers projected to offer protection. Structural data showed the vaccine-induced antibodies mimic key human bnAb interactions with the HIV envelope, providing proof-of-principle that germline-targeting vaccines can reliably induce prespecified bnAb classes under endogenous conditions and warrant further optimization for HIV vaccines.

via Nature|

#broadly-neutralizing-antibodies #germline-targeting #hiv

health1 year ago•21 min saved

Progress and Hope: The Path to Ending HIV/AIDS

The pursuit of a "functional cure" for HIV is gaining momentum, with recent clinical trials at Rockefeller University exploring the use of broadly neutralizing antibodies to maintain viral suppression without antiretroviral treatment. While complete eradication of the virus remains challenging due to its ability to hide in the body's cells, these antibodies show promise in targeting the HIV reservoir. The trials have demonstrated that some participants can maintain viral suppression for extended periods, offering hope for a future where HIV can be managed with less frequent treatments. The research underscores the importance of inclusivity in clinical trials to ensure treatments are effective for all demographics.

via POZ|

#broadly-neutralizing-antibodies #clinical-trials #functional-cure

health2 years ago•3 min saved

"New Vaccine Strategies Show Promise in Generating Broad HIV Neutralizing Antibodies"

Researchers have successfully stimulated animals' immune systems to produce precursor B cells for HIV broadly neutralizing antibodies (bNAbs), particularly targeting the gp41 region of the virus. This novel vaccine concept, tested on rhesus macaques and mice, shows promise for human application, potentially leading to a multi-step HIV vaccine regimen. The study, supported by NIH and other partners, represents a significant step toward developing a preventive HIV vaccine.

via National Institutes of Health (NIH) (.gov)|

#broadly-neutralizing-antibodies #health #hiv