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Lilly to acquire Kelonia to push off-the-shelf in vivo CAR-T for multiple myeloma
business1 month ago

Lilly to acquire Kelonia to push off-the-shelf in vivo CAR-T for multiple myeloma

Eli Lilly will acquire Kelonia Therapeutics for up to $7 billion in cash (upfront $3.25B) to gain Kelonia's in vivo gene delivery platform and KLN-1010, an in vivo anti-BCMA CAR-T therapy for multiple myeloma in Phase 1, with the aim of simplifying manufacturing and broadening access versus ex vivo CAR-T; the deal is expected to close in the second half of 2026, subject to regulatory approvals and milestone-driven payments.

via PR Newswire|
#biotechnology#business#car-t
Off-the-shelf CAR-T shows potential to delay lymphoma relapse in interim Phase 3 results
biotech1 month ago

Off-the-shelf CAR-T shows potential to delay lymphoma relapse in interim Phase 3 results

Allogene Therapeutics reported interim Phase 3 data for its off-the-shelf CAR-T therapy cema-cel in B-cell lymphoma, showing 58% MRD negativity in treated patients versus 16% in those observed with standard care, a result that could delay or prevent cancer relapse in high-risk patients, though the data are preliminary.

via statnews.com|
#allogene-therapeutics#b-cell-lymphoma#biotech
biotech1 month ago

Allogene’s off-the-shelf CAR-T shows early MRD clearance and outpatient potential in first-line LBCL (ALPHA3 interim)

Allogene Therapeutics reported interim futility data from the ALPHA3 trial in first-line consolidation LBCL, showing 58.3% MRD negativity with cemacabtagene ansegedleucel (Cema-Cel) vs 16.7% in the observation arm, a 41.6-point absolute difference that aligns with literature suggesting meaningful potential benefit. Day-45 plasma ctDNA decreased 97.7% in the Cema-Cel arm versus a 26.6% median increase in the observation arm. The regimen was generally well-tolerated with no CRS, ICANS, or GvHD and most patients managed outpatient; enrollment is ongoing with interim EFS expected in mid-2027 and primary EFS in mid-2028, and a potential BLA submission if results remain favorable. Community centers contributed about one-third of screening and infusions, underscoring broader access potential for an off-the-shelf CAR-T therapy.

via Allogene|
#alpha3#biotech#car-t
healthcare1 month ago

Off-the-shelf CAR-T cema-cel lights up MRD clearance in first-line LBCL, hinting at MRD-guided consolidation

Allogene Therapeutics reported interim futility data from the ALPHA3 trial in first-line LBCL showing cemacabtagene ansegedleucel (cema-cel) achieved MRD negativity in 58.3% of patients vs 16.7% with observation (a 41.6-point edge), and a median 97.7% drop in plasma ctDNA versus a 26.6% rise. The treatment was well tolerated with no CRS/ICANS/GvHD and most patients managed outpatient; community centers contributed about a third of activity. Enrollment aims for ~220 patients with interim EFS data due mid-2027 and primary EFS in mid-2028, and positive results could support an MRD-guided approach and potential BLA submission.

via Allogene|
#allogene-therapeutics#car-t#ctdna
CAR-T immune reset cures trio of autoimmune diseases in patient
health1 month ago

CAR-T immune reset cures trio of autoimmune diseases in patient

A 47-year-old woman with autoimmune haemolytic anaemia (AIHA), immune thrombocytopenia (ITP) and antiphospholipid syndrome (APS) achieved rapid, lasting remission after CD19-targeted CAR-T cell therapy, effectively resetting her immune system and enabling a near-normal life; she has remained in treatment-free remission for about 14 months, while researchers note the need for trials to determine durability and wider applicability.

via The Guardian|
#aiha#aps#autoimmune-diseases
From flu-like symptoms to remission: a lymphoma patient’s CAR-T comeback
health2 months ago

From flu-like symptoms to remission: a lymphoma patient’s CAR-T comeback

A Pilates instructor’s flu-like symptoms led to a diffuse large B-cell lymphoma diagnosis; after initial chemotherapy, the cancer recurred in her brain, but a personalized CAR-T immunotherapy treatment induced complete remission. She experienced no major side effects, returned to daily life, and will continue regular scans to monitor for recurrence, marking a hopeful turnaround.

via CBS News|
#car-t#diffuse-large-b-cell-lymphoma#health
business3 months ago

Gilead to Acquire Arcellx for $7.8B to Accelerate Anito-cel and CAR-T Platform

Gilead will acquire Arcellx for $115 per share in cash plus a $5-per-share contingent value right (CVR), valuing the deal at about $7.8 billion and giving Gilead full control of Anito-cel, its BCMA-directed CAR-T therapy for multiple myeloma. The transaction aims to accelerate development and commercialization, with Anito-cel’s BLA accepted by the FDA and a PDUFA date of December 23, 2026; the deal is expected to close in Q2 2026 and to be accretive to EPS after FDA approval, with the CVR tied to cumulative global net sales milestones through 2029.

via Gilead Sciences|
#anito-cel#arcellx#business
Gilead buys Arcellx for $7.8B to bolster CAR-T push against Carvykti
business3 months ago

Gilead buys Arcellx for $7.8B to bolster CAR-T push against Carvykti

Gilead agreed to acquire Arcellx for about $7.8 billion in cash to take full control of the BCMA-targeted CAR-T therapy anito-cel as FDA review proceeds, paying $115 a share—a 68% premium to Arcellx's 30-day VWAP with a $5-per-share contingent payout if global sales reach $6 billion by 2029; the deal aims to sharpen Gilead's cell-therapy portfolio and compete with J&J/Legend's Carvykti, with analysts noting anito-cel's safety profile and potential to restore momentum for Gilead's Kite unit.

via Fierce Biotech|
#biotech#business#car-t
Gilead to Acquire Arcellx in $7.8 Billion CAR-T Focused Deal
business3 months ago

Gilead to Acquire Arcellx in $7.8 Billion CAR-T Focused Deal

Gilead will buy Arcellx for $7.8 billion in cash, valuing Arcellx at $115 per share with a 79% premium and expanding their joint development of the anti-cancer CAR-T therapy anito-cel for multiple myeloma. The deal follows Arcellx's collaboration with Kite Pharma, and the FDA is reviewing anito-cel with a decision expected by year-end. The acquisition is expected to be EPS-accretive in 2028 and includes a $5 per share milestone payment if cumulative global net sales of anito-cel reach $6 billion through 2029.

via CNBC|
#arcellx#biotech#business
Lilly to Acquire Orna Therapeutics to Accelerate In Vivo CAR-T
biotech-healthcare3 months ago

Lilly to Acquire Orna Therapeutics to Accelerate In Vivo CAR-T

Eli Lilly will acquire Orna Therapeutics in a deal worth up to $2.4 billion in cash, expanding Lilly’s genetic-medicine platform with Orna’s circular-RNA–based in vivo CAR-T technology (ORN-252) designed to treat B cell–driven autoimmune diseases, leveraging lipid nanoparticle delivery for potentially more durable therapeutic protein expression and broader in vivo cell-therapy options.

via PR Newswire|
#biotech-healthcare#car-t#circular-rna
Twenty Years of Cancer Advances Raise U.S. Five-Year Survival to 70%
science4 months ago

Twenty Years of Cancer Advances Raise U.S. Five-Year Survival to 70%

A 75th American Cancer Society Cancer Statistics report shows the U.S. five-year cancer survival rate has risen to about 70% (7‑in‑10) thanks to earlier detection and new treatments like immune checkpoint therapy and CAR‑T cell therapy. Survival has improved across cancers (breast 92%, melanoma 95%, prostate 98%), with leukemia and non‑Hodgkin lymphoma up ~20% and 18% and pancreatic and liver cancers also rising (to 13% and 22%). Myeloma and lung cancer survival have climbed to 62% and 15–28%, while late-stage survival now averages 35% (up from 17%). The death rate has fallen about 34% since 1991, saving roughly 4.8 million lives by 2023 — achievements driven by diagnosis, screening, and innovative therapies rather than a cure.

via Good News Network|
#cancer-research#cancer-survival#car-t
NHS administers pioneering CAR-T leukemia therapy to first patient, hailed as sci‑fi
health4 months ago

NHS administers pioneering CAR-T leukemia therapy to first patient, hailed as sci‑fi

The NHS has funded and begun delivering CAR-T cell therapy for adults with B‑cell ALL, with 28‑year‑old Oscar Murphy receiving the first infusion in Manchester. The personalised “living drug” reprograms a patient’s T‑cells to attack cancer and could extend survival; trial data showed 77% remission and about 15.6 months of added life, with around 50 patients a year expected to benefit across the UK.

via BBC|
#cancer#car-t#health