All articles tagged with #autoimmune
Five years after a lupus patient achieved lasting remission with CAR-T therapy, the case has stirred broad pharma interest and spurred ongoing research into CAR-T for autoimmune diseases, offering renewed hope while highlighting challenges ahead.
New research from the University of Basel shows that gut bacteria resembling myelin can trigger or slow multiple sclerosis progression in mice, highlighting both risks and potential for microbiome-based treatments that train the immune system to tolerate myelin.
A global increase in psoriasis, a chronic inflammatory skin condition, is notably higher in wealthier regions like North America and Western Europe, with cases rising over 86% since 1990. Factors such as better diagnosis, hygiene practices, and immune system responses are believed to contribute, although no cure exists, and management involves topical treatments and light therapy.
Winter worsens autoimmune symptoms due to factors like reduced vitamin D synthesis, disrupted melatonin levels, increased susceptibility to infections, poor diet, and decreased physical activity. Preventive strategies include vitamin D supplementation, optimizing sleep and light exposure, maintaining a healthy diet, and staying active indoors to reduce flare-ups and improve immune stability.
Stanford Medicine researchers have linked the Epstein-Barr virus (EBV), which most people carry, to the development of lupus by showing how infected B cells can trigger autoimmune responses, potentially opening new avenues for treatment and prevention.
Early data from Neutrolis suggests that a DNA-chopping enzyme that breaks up neutrophil extracellular traps (NETs) could offer a new approach to treating autoimmune diseases by targeting a unique immune mechanism.
The FDA has approved a new neck implant that stimulates the vagus nerve to treat rheumatoid arthritis by reducing inflammation, offering a potential alternative for patients unresponsive to traditional drugs. The device delivers brief daily electrical pulses, is safe for most adults, and may help manage other inflammatory conditions in the future.
A study suggests ALS may be an autoimmune disease where CD4+ T cells attack neuron proteins, with patients showing different survival times based on their immune response; boosting protective T cells could lead to new treatments.
Scientists have discovered that rheumatoid arthritis (RA) begins years before symptoms appear, with changes in immune system profiles detectable in at-risk individuals. Elevated autoantibodies like ACPA and RF can predict RA development, but not all with these antibodies develop the disease. Recent research highlights immune system alterations, such as increased inflammatory proteins and activated B and T cells, in individuals before clinical symptoms emerge, offering potential for early detection and preventive therapies. These findings could lead to interventions that prevent or mitigate RA progression.
Recent studies reveal a significant link between air pollution and the triggering or worsening of psoriasis, an autoimmune skin condition, with pollutants like PM2.5 and PAHs contributing to inflammation and immune activation. Individuals in polluted environments, such as those near sugarcane burning or factories, are at increased risk, highlighting the need for regulatory action and personal protective measures.
Cassandra Smith, a 30-year-old with rheumatoid arthritis and obesity, experienced significant health improvements—including no flare-ups and substantial weight loss—after starting compounded tirzepatide, a GLP-1 medication, which also helped her improve her quality of life and mental health.
A new study finds that exposure to common Pfas chemicals alters gene activity, which is linked to various health problems including cancers, neurological disorders, and autoimmune diseases. The research, involving firefighters exposed to high Pfas levels, highlights how these chemicals impact gene expression and biological pathways associated with multiple diseases, paving the way for potential treatments and further disease identification.
Novartis announced positive results from its Phase III trials of ianalumab, demonstrating significant improvement in disease activity for Sjögren’s disease, potentially making it the first targeted treatment for this autoimmune disorder. The trials showed the drug was well tolerated and could soon be submitted for regulatory approval.
The article highlights important but often overlooked facts about women's health, emphasizing the need for better research, awareness, and personalized care, while encouraging women to trust their bodies and seek second opinions when necessary.
The UK has begun administering teplizumab, a groundbreaking drug that delays the onset of type 1 diabetes by targeting the immune system before symptoms appear, representing a shift from managing to potentially preventing the disease through early detection and intervention.