All articles tagged with #ckd
A 10-year Norwegian cohort of 1,324 middle-aged and older adults measured iohexol-based GFR and found that higher habitual protein intake (mean 1.2 g/kg/d) was not associated with faster GFR decline, accelerated decline, or incident CKD, suggesting protein restriction may not prevent CKD. Limitations include FFQ-based protein estimates and lack of 24-hour urinary urea validation.
Novo Nordisk's Zeus phase 3 trial of ziltivekimab failed to reduce major adverse cardiovascular events in patients with CKD and inflammation, despite IL-6 pathway inhibition; the hazard ratio was 0.99, missing the clinically meaningful 0.85 target and causing the trial to miss its primary endpoint. Artemis and Hermes remain the next tests, though analysts have grown skeptical, given the potential multibillion-dollar CKD opportunity and a peak sales projection around $3 billion previously attached to the program. Readouts for Artemis/Hermes are expected in the first half of next year, leaving the pipeline contingent on those results.
In a prospective UK cohort of 1,732 stage 3 CKD patients, lower creatinine muscle index (CMI) was tied to higher all-cause mortality and CKD progression over 5 years, while higher waist-to-hip ratio (WHR) predicted more cardiovascular events; age, male sex, higher urine albumin:creatinine ratio, and lower serum albumin also increased risk.
Chronic kidney disease (CKD) affects nearly 800 million people worldwide and is among the top 10 causes of death, often remaining asymptomatic in early stages. Key risk factors include high blood pressure, high blood glucose, and high BMI. Early detection through regular testing and managing risk factors can slow progression and prevent severe complications.
Researchers discovered that a constipation drug, lubiprostone, can slow kidney function decline in CKD patients by improving gut microbiota and mitochondrial health, showing promise as a new treatment approach.
A study links chronic kidney disease, especially in dialysis patients, to a higher risk of Restless Legs Syndrome (RLS), which is associated with iron deficiency in the brain. RLS causes uncontrollable leg urges, worsens at night, and impacts sleep and mental health. Managing RLS involves addressing underlying conditions like iron deficiency, lifestyle changes, and symptom relief methods, although there is no cure.