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Csf

All articles tagged with #csf

science24 days ago•37 min saved

Yawning May Help Clear the Brain, MRI Study Finds

A UNSW-led study used MRI to watch 22 healthy participants yawning, deep-breathing, and resting. Yawns moved cerebrospinal fluid away from the brain (unlike deep breaths), while both yawns and deep breaths increased blood flow leaving the brain. The findings suggest yawning could play a role in brain cleaning or cooling, and that yawning patterns are highly individual, likely governed by a central pattern generator; the study was published in Respiratory Physiology & Neurobiology (2026).

via Yahoo|

#brain #cerebrospinal-fluid #csf

science2 months ago•6 min saved

Brain gatekeepers clear tau: Alzheimer’s may cripple this cleanup

Specialized brain cells called tanycytes clear tau proteins from cerebrospinal fluid into the bloodstream, helping remove potentially toxic tau from the brain. In Alzheimer's disease, tanycytes are damaged and less tau moves to the blood, correlating with brain tau buildup; this reveals a potential mechanism for disease progression and a new target to boost tau clearance.

via Nature|

#alzheimers-disease #blood-brain-barrier #csf

science3 months ago•71 min saved

Skull bone marrow drives immunotolerance in pediatric brain tumors

New research reveals a skull bone marrow–tumor immune axis in childhood brain cancers: CSF-borne signals educate skull hematopoietic stem and progenitor cells to present tumor antigens via MHC-II, polarizing CD4+ T cells toward regulatory T cells and promoting immunotolerance. Disrupting this axis—by normalizing CSF cytokines, mobilizing skull hematopoiesis, or blocking GM-CSF signaling with mavrilimumab (and even more so when combined with immune checkpoint blockade)—induces tumor regression in mouse models of ZFTA–RELA ependymoma, choroid plexus carcinoma, and group 3 medulloblastoma. The findings identify a skull-tumor immunological interface and suggest targeting local skull hematopoiesis as a potentially less-toxic therapy for aggressive pediatric brain tumors.

via Nature|

#csf #hspcs #immunotolerance

health2 years ago•8 min saved

"Proteomics Reveals Early Markers for Autosomal Dominant AD"

Two recent preprints describe proteomic studies that have identified potential biomarkers for early Alzheimer's disease. One study focused on individuals with autosomal dominant Alzheimer's disease (AD) and found 125 proteins in the cerebrospinal fluid (CSF) that distinguished carriers of familial AD mutations from noncarriers, with extracellular matrix protein SMOC1 potentially being an early biomarker. Another study examined plasma proteins in sporadic AD and identified 100 proteins more abundant in AD patients, with eight proteins associated with cognitive decline. These findings suggest that proteomic markers may be specific to CSF or plasma and could aid in early diagnosis and understanding of AD pathology.

via Alzforum|

#alzheimers-disease #biomarkers #csf

health3 years ago•19 min saved

Using Blood Biomarkers for Alzheimer's Diagnosis and Treatment.

Researchers have identified several blood biomarkers that can aid in the diagnosis and monitoring of Alzheimer's disease, including CSF biomarkers such as Aβ42/Aβ40 and p-tau217, as well as plasma biomarkers such as β-amyloid 42/40 and phospho-tau217. These biomarkers have been shown to correlate with amyloid and tau pathology in the brain, and can be used in clinical practice and trials to track disease progression and response to treatment.

via Nature.com|

#alzheimers-disease #biomarkers #clinical-trials