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Diffuse Midline Glioma

All articles tagged with #diffuse midline glioma

medicine21 days ago•48 min saved

Levetiracetam targets DMG’s growth drivers, boosting survival in a tumor subclass

Retrospective data from multiple centers show levetiracetam use is linked to longer overall survival in pediatric diffuse midline glioma (DMG) but not in hemispheric high-grade gliomas. In DMG models, levetiracetam reduces tumor growth and extends survival by selectively dampening low-frequency GABAergic neuron-to-glioma synaptic transmission through a brain-tumor–specific, SV2A-independent mechanism; brivaracetam (SV2A-targeted) did not reproduce this effect. The findings suggest a DMG-specific therapeutic avenue that warrants prospective trials, with caveats including small sample sizes and retrospective design.

via Nature|

#diffuse-midline-glioma #gabaergic-synapses #levetiracetam

sports2 months ago•4 min saved

Pacers guard Haliburton donates $10K to family of young cancer victim, praised by Charlotte Flair

Indiana Pacers guard Tyrese Haliburton donated $10,000 to a GoFundMe for the family of 8-year-old Scarlett Guillen, who died after a battle with a rare brain cancer. Charlotte Flair publicly thanked him, saying the gift helped cover funeral costs and highlighting the impact of his generosity on the family and fans who loved Scarlett; Flair had previously honored Scarlett as her biggest fan with butterfly-themed gear.

via Fox News|

#charlotte-flair #diffuse-midline-glioma #gofundme

science3 months ago•103 min saved

Brain-wide network links prognosis to pediatric diffuse midline glioma survival

Researchers mapped the brain-wide connectivity of pediatric diffuse midline gliomas (DMG) and defined a conserved DMG network whose connectivity to each patient’s tumor independently predicts overall survival across two external validation cohorts. The DMG network shows tumor growth trajectories and metabolic changes that peak within development-aligned windows, with single-nucleus RNA-seq revealing enriched synaptic genes in high-connectivity DMG. Structural-connectome analyses reproduce the network, spinal metastases preferentially involve DMG network nodes, and incidental resection of high-connectivity tissue is associated with longer survival, suggesting DMGs exploit intact brain circuits. Together, these findings propose a prognostic brain network in DMG that could inform surgical strategies and future therapies.

via Nature|

#diffuse-midline-glioma #dmg #functional-connectivity