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Eif5a2

All articles tagged with #eif5a2

science2 months ago•4 min saved

Cancer Harnesses Anti-Aging Polyamines to Accelerate Growth, Study Finds

A Tokyo University of Science study shows polyamines like spermidine—long touted for anti-aging potential—can promote cancer cell growth by boosting the translation factor eIF5A2 and shifting cells to aerobic glycolysis; removing polyamines or eIF5A2 slows cancer cell growth in lab cultures, while spermidine can reactivate it. While the findings highlight potential new cancer drug targets, they are based on cell cultures and do not claim that polyamines cause cancer—only that cancer cells can hijack these pathways to proliferate.

via ScienceAlert|

#aerobic-glycolysis #cancer #eif5a2

health-and-medicine2 months ago•7 min saved

Longevity Molecules May Fuel Cancer, Study Finds

Polyamines—molecules linked to longevity via autophagy and eIF5A1—also promote cancer by increasing eIF5A2 and certain ribosomal proteins, boosting glycolysis and tumor growth. The findings show these compounds have opposite effects in normal versus cancerous cells and point to targeting eIF5A2 as a potential cancer therapy while preserving any anti-aging benefits.

via ScienceDaily|

#aging #cancer #eif5a1

science3 months ago•8 min saved

Longevity Molecules May Fuel Cancer Growth Through a Hidden Pathway

New research from Tokyo University of Science shows polyamines—long linked to anti-aging effects via autophagy and mitochondria—can promote cancer by upregulating the translation factor eIF5A2 and boosting glycolysis, while altering ribosomal protein production. The study found polyamines lift suppression of eIF5A2 by miR-6514-5p, activating a cancer-promoting program distinct from eIF5A1’s aging-related role, suggesting context matters for polyamine supplements and identifying a potential target for cancer therapy.

via SciTechDaily|

#autophagy #cancer-metabolism #eif5a2