ERBB4 receptor may be early driver of Alzheimer's, opening new therapeutic path
South Korean researchers identify ERBB4 receptor misexpression in excitatory neurons as an early driver of Alzheimer’s pathology. In mouse models, removing ERBB4 calmed hyperactive neurons, reduced reactive glial activity and plaques, and improved memory, while post-mortem human tissue showed elevated ERBB4 in affected neurons, suggesting ERBB4 as a potential therapeutic target across neurodegenerative diseases.
