All articles tagged with #genomic imprinting
Researchers at Shanghai Jiao Tong University successfully created fertile adult mice from embryos with only paternal DNA by precisely editing imprinting control regions using CRISPR, revealing that genomic imprinting is a key barrier to uniparental mammalian development and opening new avenues in reproductive biology.
Scientists at the Van Andel Institute have discovered a key part of the mechanism responsible for annotating genetic information passed from fathers to their offspring. This process, known as genomic imprinting, involves the switching off of a gene from one parent while the copy from the other parent remains active. Errors in imprinting have been linked to diseases such as Silver-Russell syndrome, certain cancers, and diabetes. The researchers identified an RNA mechanism that governs the establishment of imprinting and sheds light on why it differs between fathers and mothers. This finding provides valuable insights into the regulation of genomic imprinting and its implications for lifelong health.